Chronic kidney disease is common in sickle cell disease: a cross-sectional study in the Tema Metropolis, Ghana.
Chronic kidney disease is common in sickle cell disease: a cross-sectional study in the Tema Metropolis, Ghana.
复制标题
DOI：
10.1186/s12882-015-0072-y
复制
发表时间：
2015-05-29
期刊：
影响因子：
2.3
通讯作者：
Adoba P
中科院分区：
文献类型：
--
作者：
Ephraim RK;Osakunor DN;Cudjoe O;Oduro EA;Asante-Asamani L;Mitchell J;Agbodzakey H;Adoba P
镰状细胞病（SCD）的肾脏受累对发病率和死亡率有重要影响。本研究的目的是确定慢性肾脏疾病（CKD）在SCD患者中的患病率，以及血红蛋白基因型之间的基本临床变量差异。2013年12月至2014年5月在Tema总医院镰状细胞诊所进行的一项基于医院的横断面研究。194名SCD患者在门诊镰状细胞诊所接受医疗护理，被纳入研究。通过结构化的问卷调查获得人口统计、临床病史、血压和人体测量的信息。取血、尿分别测定血清肌酐和蛋白尿。使用CKD-EPI和Schwartz方程计算估计的GFR （eGFR）。CKD是根据肾脏疾病改善全球结局（KDIGO）指南定义的。采用GraphPad棱镜进行分析，P <0.05为差异有统计学意义。39.2%的参与者存在CKD。使用KDIGO指南，40.8%的HbSS参与者患有1期CKD，没有2期CKD。此外，30.8%的HbSC参与者患有1期CKD， 3.8%患有2期CKD。CKD分期中年龄有增加的趋势，2期CKD参与者年龄最大（P < 0.001）。目前的研究结果表明CKD在SCD患者中很常见，并且随着年龄的增长患病率和强度增加。蛋白尿和CKD在HbSS基因型中比在HbSC基因型中更常见。本文的在线版本（doi:10.1186/s12882-015-0072-y）包含补充材料，仅供授权用户使用。
Renal involvement in sickle cell disease (SCD) contributes significantly to morbidity and mortality. The aim of this study was to determine the prevalence of chronic kidney disease (CKD) amongst SCD patients, and how basic clinical variables differ across haemoglobin genotypes. A hospital-based cross-sectional study conducted from December 2013 to May 2014 at the Sickle cell clinic of the Tema General Hospital. One hundred and ninety-four (194) participants with SCD, receiving medical care at the outpatient sickle cell clinic were enrolled onto the study. A structured questionnaire was administered to obtain information on demography, clinical history, blood pressure and anthropometry. Blood and urine samples were taken for serum creatinine and proteinuria determination respectively. The estimated GFR (eGFR) was calculated using the CKD-EPI and Schwartz equations. CKD was defined according to the Kidney Disease Improving Global Outcomes (KDIGO) guidelines. Analysis was performed using GraphPad prism and P <0.05 was considered statistically significant. CKD was present in 39.2 % of participants. Using KDIGO guidelines, 40.8 % of the HbSS participants had stage 1 CKD and none had stage 2 CKD. In addition, 30.8 % of the HbSC participants had stage 1 CKD and 3.8 % had stage 2 CKD. There was a trend of increasing age across CKD stages and stage 2 CKD participants were oldest (P < 0.001). Results from the current study suggest that CKD is common amongst SCD patients and prevalence and intensity increases with age. Proteinuria and CKD was more common in HbSS genotype than in HbSC genotype. The online version of this article (doi:10.1186/s12882-015-0072-y) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
158.5
作者：
PLATT, OS;BRAMBILLA, DJ;KLUG, PP
通讯作者：
KLUG, PP
影响因子：
2.3
作者：
Arlet, Jean-Benoit;Ribeil, Jean-Antoine;Courbebaisse, Marie
通讯作者：
Courbebaisse, Marie
影响因子：
2.6
作者：
Gosmanova, Elvira O.;Zaidi, Sahar;Adams-Graves, Patricia E.
通讯作者：
Adams-Graves, Patricia E.
影响因子：
20.3
作者：
Belhassen, L;Pelle, G;Adnot, S
通讯作者：
Adnot, S
影响因子：
39.2
作者：
Levey AS;Stevens LA;Schmid CH;Zhang YL;Castro AF 3rd;Feldman HI;Kusek JW;Eggers P;Van Lente F;Greene T;Coresh J;CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
通讯作者：
CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)