APPLICATION OF DOPPLER OPTICAL COHERENCE TOMOGRAPHY IN RHEOLOGICAL STUDIES: BLOOD FLOW AND VESSELS MECHANICAL PROPERTIES EVALUATION
APPLICATION OF DOPPLER OPTICAL COHERENCE TOMOGRAPHY IN RHEOLOGICAL STUDIES: BLOOD FLOW AND VESSELS MECHANICAL PROPERTIES EVALUATION
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DOI：
10.1142/s179354580900067x
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发表时间：
2009-10-01
影响因子：
2.5
通讯作者：
Matcher, Stephen
中科院分区：
文献类型：
--
作者：
Bonesi, Marco;Kennerley, Aneurin J.;Matcher, Stephen
多普勒光学相干断层扫描 (DOCT) 是一种无创光学诊断技术，非常适合微流速度剖面的定量绘图和流管相互作用的分析。许多生物医学应用都需要对复杂结构血管床中的血流进行无创成像和定量分析，包括那些确定血管机械性能或了解血流与容纳介质之间的机械相互作用发挥关键作用的应用。微血管壁弹性的变化可能是早期心血管疾病的潜在指标，同时监测血流动力学以及血管壁剪切应力的相关时间和空间变化可以帮助预测动脉粥样硬化斑块可能的破裂。介绍了应用 DOCT 评估弹性血管模型力学性能的可行性研究结果。该技术还应用于大鼠颅下血流的体内成像。
Doppler Optical Coherence Tomography (DOCT) is a noninvasive optical diagnostic technique, which is well suited for the quantitative mapping of microflow velocity profiles and the analysis of flow-vessel interactions. The noninvasive imaging and quantitative analysis of blood flow in the complex-structured vascular bed is required in many biomedical applications, including those where the determination of mechanical properties of vessels or the knowledge of the mechanic interactions between the flow and the housing medium plays a key role. The change of microvessel wall elasticity could be a potential indicator of cardiovascular disease at the very early stage, whilst monitoring the blood flow dynamics and associated temporal and spatial variations in vessel's wall shear stress could help predicting the possible rupture of atherosclerotic plaques. The results of feasibility studies of application of DOCT for the evaluation of mechanical properties of elastic vessel model are presented. The technique has also been applied for imaging of sub-cranial rat blood flow in vivo.