Three-dimensional, unsteady simulation of alveolar respiration.
Three-dimensional, unsteady simulation of alveolar respiration.
复制标题
肺泡呼吸的三维非稳态模拟。
DOI：
10.1115/1.1504445
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
JohnsonJr,RobertL
中科院分区：
文献类型：
--
作者：
Kulish,VladimirV;Lage,JoséL;Hsia,ConnieCW;JohnsonJr,RobertL
一种新的宏观气体传输模型，来自基本的工程原理，被用来模拟三维的，不稳定的呼吸过程内的肺泡区域的肺。模拟，模仿单呼吸技术测量肺弥散量的一氧化碳（CO），允许预测的红细胞（RBC）分布对肺弥散量的影响。通过数值模拟获得的结果揭示了分布类型与肺扩散能力之间的密切关系。考虑了几种RBC分布，即：正态（随机）、均匀、中心簇和角簇红细胞分布。一个无量纲的相关性得到的几何参数表征的RBC分布，并提出作为一个有用的工具，用于预测RBC分布对肺弥散量的影响。本研究未考虑红细胞移动的影响，因为在毛细血管中血液所花费的时间内，CO不会与毛细血管血液平衡。因此，预计血流对CO扩散的影响仅为轻微。
A novel macroscopic gas transport model, derived from fundamental engineering principles, is used to simulate the three-dimensional, unsteady respiration process within the alveolar region of the lungs. The simulations, mimicking the single-breath technique for measuring the lung diffusing capacity for carbon-monoxide (CO), allow the prediction of the red blood cell (RBC) distribution effects on the lung diffusing capacity. Results, obtained through numerical simulations, unveil a strong relationship between the type of distribution and the lung diffusing capacity. Several RBC distributions are considered, namely: normal (random), uniform, center-cluster, and corner-cluster red cell distributions. A nondimensional correlation is obtained in terms of a geometric parameter characterizing the RBC distribution, and presented as a useful tool for predicting the RBC distribution effect on the lung diffusing capacity. The effect of red cell movement is not considered in the present study because CO does not equilibrate with capillary blood within the time spent by blood in the capillary. Hence, blood flow effect on CO diffusion is expected to be only marginal.