The genetic/metabolic transformation concept of carcinogenesis.
The genetic/metabolic transformation concept of carcinogenesis.
复制标题
DOI：
10.1007/s10555-011-9334-8
复制
发表时间：
2012-06
影响因子：
9.2
通讯作者：
Franklin, Renty B.
中科院分区：
文献类型：
--
作者：
Costello, Leslie C.;Franklin, Renty B.
关键词：
对致癌过程的了解很少，并且存在不同的概念和观点。关于改变的细胞中间代谢在癌症的发展和进展中的作用，已经引起了人们重新的兴趣。因此，对代谢改变在癌症发展中的意义存在不同的看法。这些概念都没有认识到并将细胞代谢的原理纳入细胞活性，这适用于所有细胞，包括致癌过程。本报告结合了一个新的概念，致癌，包括“遗传/代谢”的转化，包括这些原则的细胞代谢细胞活性。中间代谢转化对于提供恶性肿瘤的生物能量/合成、生长/增殖和迁移/侵袭事件是必不可少的。该概念涉及“致癌转化”，用于从其前体正常细胞发展成肿瘤细胞;以及所需的“遗传/代谢”转化，用于促进肿瘤细胞发展成恶性细胞，并表现出恶性过程。这种概念揭示了癌症发生的阶段和事件，为生物标志物的鉴定和治疗剂的开发提供了方法。该报告讨论了遗传学和蛋白质组学在改变癌症细胞代谢中的当代应用;并强调了遗传学和蛋白质组学与生物化学和代谢研究适当整合的重要性，以及不适当研究的后果。
The carcinogenesis process is poorly understood and subject to varying concepts and views. A rejuvenated interest has arisen regarding the role of altered cellular intermediary metabolism in the development and progression of cancer. As a result, differing views of the implications of altered metabolism in the development of cancer exist. None of the concepts recognize and incorporate the principles of cell metabolism to cell activity, which are applicable to all cells including the carcinogenesis process. This presentation incorporates a novel concept of carcinogenesis that includes a “genetic/metabolic” transformation that encompasses these principles of cell metabolism to cell activity. The intermediary metabolism transformation is essential to provide the bioenergetic/ synthetic, growth/proliferation, and migration/invasive events of malignancy. The concept invokes an “oncogenetic transformation” for the development of neoplastic cells from their precursor normal cells; and a required “genetic/metabolic” transformation for facilitation of the development of the neoplastic cells to malignant cells with the manifestation of the malignant process. Such a concept reveals stages and events of carcinogenesis that provide approaches for the identification of biomarkers and for development of therapeutic agents. The presentation discusses the contemporary application of genetics and proteomics to altered cellular metabolism in cancer; and underscores the importance of proper integration of genetics and proteomics with biochemical and metabolic studies, and the consequences of inappropriate studies.
登录
查看更多内容
恶性和非恶性人类前列腺组织中的线粒体顺乌头酸酶和柠檬酸代谢。
影响因子：
37.3
作者：
Singh, Keshav K.;Desouki, Mohamed M.;Franklin, Renty B.;Costello, Leslie C.
通讯作者：
Costello, Leslie C.
影响因子：
37.3
作者：
Costello, Leslie C;Franklin, Renty B
通讯作者：
Franklin, Renty B
影响因子：
4.8
作者：
Johnson, Leslie A.;Kanak, Mazhar A.;Bagasra, Omar
通讯作者：
Bagasra, Omar
影响因子：
4.4
作者：
Costello, LC;Guan, ZX;Franklin, RB
通讯作者：
Franklin, RB
影响因子：
3.3
作者：
Alqawi, Omar;Wang, Hong P.;Singh, Gurmit
通讯作者：
Singh, Gurmit