Metabolomics in the developmental origins of obesity and its cardiometabolic consequences.
Metabolomics in the developmental origins of obesity and its cardiometabolic consequences.
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DOI：
10.1017/s204017441500001x
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发表时间：
2015-04
影响因子：
1.7
通讯作者：
Gillman MW
中科院分区：
文献类型：
--
作者：
Hivert MF;Perng W;Watkins SM;Newgard CS;Kenny LC;Kristal BS;Patti ME;Isganaitis E;DeMeo DL;Oken E;Gillman MW
在这篇综述中，我们讨论了代谢组学的潜在作用，以加强对肥胖相关的健康和疾病的发育起源(DOHAD)的理解。我们首先提供常见技术和分析方法的概述，以帮助感兴趣的研究人员潜入这个相对新颖的领域。接下来，我们描述代谢组学如何捕捉出出了名的难以量化的暴露，并帮助进一步提炼与过度肥胖相关的表型和生命过程中相关的代谢后遗症。总而言之，这些数据最终可以帮助阐明胎儿代谢编程的基础机制。最后，我们回顾了目前的知识差距，并确定了代谢组学领域可能为人类群体中与DOHaD相关的机制提供洞察力的领域。
In this review, we discuss the potential role of metabolomics to enhance understanding of obesity-related developmental origins of health and disease (DOHaD). We first provide an overview of common techniques and analytical approaches to help interested investigators dive into this relatively novel field. Next, we describe how metabolomics may capture exposures that are notoriously difficult to quantify, and help to further refine phenotypes associated with excess adiposity and related metabolic sequelae over the life course. Together, these data can ultimately help to elucidate mechanisms that underlie fetal metabolic programming. Finally, we review current gaps in knowledge and identify areas where the field of metabolomics is likely to provide insights into mechanisms linked to DOHaD in human populations.