Weekly high-dose folic acid supplementation is effective in lowering serum homocysteine concentrations in women
Weekly high-dose folic acid supplementation is effective in lowering serum homocysteine concentrations in women
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DOI：
10.1159/000069278
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发表时间：
2003-03-01
影响因子：
3.9
通讯作者：
Briars, B
中科院分区：
文献类型：
--
作者：
Adank, C;Green, TJ;Briars, B
目的：比较每周一次高剂量（2,800 μ g）叶酸补充剂与每日一次（400 μ g）叶酸补充剂在降低健康育龄妇女同型半胱氨酸浓度方面的疗效。研究方法：自由生活的健康育龄妇女（n = 138）随机接受每周（2,800 μ g），每日（400 μ g）叶酸补充剂或安慰剂。在基线和12周时采集血样，分析血清同型半胱氨酸和红细胞叶酸。结果如下：在第12周，接受每日补充[第12周-基线：-1.4（-2.0，-0.70）mumol/l]和每周补充[-1.3（-2.1，-0.5）mumol/l]的妇女与安慰剂[0.0（-0.5，0.5）mumol/l]相比，平均（95%CI）血清同型半胱氨酸浓度显著下降（p < 0.05）。两个叶酸治疗组之间无显著差异（p > 0.05）。在12周时，两个补充组的平均红细胞叶酸浓度与安慰剂组相比显著增加（p < 0.001）。每日给药组的红细胞叶酸增加量明显大于（p < 0.001）每周给药组[451（380，521）vs. 288（240，335）nmol/l]。结论：每周一次的高剂量叶酸补充剂在降低健康育龄妇女的同型半胱氨酸浓度方面与每日一次补充剂一样有效。需要进一步的研究来确定每周补充叶酸是否能有效降低高同型半胱氨酸人群的同型半胱氨酸浓度。版权所有（C）2003 S. Karger AG，巴塞尔。
Aims: To compare the efficacy of a weekly high-dose (2,800 mug) folic acid supplement with a daily (400 mug) folic acid supplement in lowering homocysteine concentrations in healthy women of childbearing age. Methods: Free-living healthy women of childbearing age (n = 138) were randomized to receive a weekly (2,800 mug), a daily (400 mug) folic acid supplement, or placebo. Blood samples were collected at baseline and at 12 weeks and analyzed for serum homocysteine and erythrocyte folate. Results: At 12 weeks the mean (95% CI) serum homocysteine concentrations declined significantly (p < 0.05) in women receiving the daily [week 12 - baseline: -1.4 (-2.0, -0.70) mumol/l] and the weekly supplement [-1.3 (-2.1,-0.5) mumnol/l] versus placebo [0.0 (-0.5, 0.5) mumol/l]. There was no significant difference between the two folate-treated groups (p > 0.05). At 12 weeks the mean erythrocyte folate concentration increased significantly in both supplemented groups versus placebo (p < 0.001). The increase in erythrocyte folate was significantly greater (p < 0.001) in the daily group than in the weekly group [451 (380, 521) vs. 288 (240, 335) nmol/l]. Conclusion: A weekly high-dose folic acid supplement was as effective as a daily supplement in lowering homocysteine concentrations in healthy women of childbearing age. Further study is needed to determine if weekly folic acid supplementation is effective in lowering homocysteine concentrations in populations with high homocysteine. Copyright (C) 2003 S. Karger AG, Basel.