Cytotoxic Bipyridines from the Marine-Derived Actinomycete Actinoalloteichus cyanogriseus WH1-2216-6
Cytotoxic Bipyridines from the Marine-Derived Actinomycete Actinoalloteichus cyanogriseus WH1-2216-6
复制标题
来自海洋源放线菌 Actinoalloteichuscyanogriseus WH1-2216-6 的细胞毒性联吡啶
DOI：
10.1021/np200258h
复制
发表时间：
2011-08-01
影响因子：
5.1
通讯作者：
Zhu, Weiming
中科院分区：
文献类型：
--
作者：
Fu, Peng;Wang, Shuxia;Zhu, Weiming
从海洋放线菌Actinoalloteichus cyanogriseus WH 1 -2216-6中分离得到五个新的联吡啶生物碱（1-5）和一个新的苯基吡啶生物碱（6），我们将其与五个已知的类似物（7-11）一起沿着命名为caerulomycins F-K。化合物1-6的结构经波谱分析和化学方法确证。化合物1-10显示出对HL-60、K562、KB和A549细胞系的细胞毒性，IC 50值为0.26 - 15.7 μ M。化合物7和8还显示出对大肠杆菌、产气杆菌、铜绿假单胞菌和白色念珠菌的抗微生物活性，MIC值为9.7至38.6 μ M。
Five new bipyridine alkaloids (1-5) and a new phenylpyridine alkaloid (6), which we name caerulomycins F-K, along with five known analogues (7-11), were isolated from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6. The structures of 1-6 were established on the basis of spectroscopic analyses and chemical methods. Compounds 1-10 showed cytotoxicity against the HL-60, K562, KB, and A549 cell lines, with IC50 values of 0.26 to 15.7 mu M. Compounds 7 and 8 also showed antimicrobial activities against Escherichia coli, Aerobacter aerogenes, Pseudomonas aeruginosa, and Candida albicans, with MIC values of 9.7 to 38.6 mu M.