Asymmetric organocatalytic three-component 1,3-dipolar cycloaddition: Control of stereochemistry via a chiral bronsted acid activated dipole
Asymmetric organocatalytic three-component 1,3-dipolar cycloaddition: Control of stereochemistry via a chiral bronsted acid activated dipole
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不对称有机催化三组分1,3-偶极环加成：通过手性布朗斯台德酸活化偶极子控制立体化学
DOI：
10.1021/ja801034e
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发表时间：
2008-04-30
影响因子：
15
通讯作者：
Gong, Liu-Zhu
中科院分区：
文献类型：
--
作者：
Chen, Xiao-Hua;Zhang, Wen-Quan;Gong, Liu-Zhu
在Bronsted酸催化下，由联二醇衍生的双磷酸催化醛、氨基酯和亲偶极试剂之间的三组分不对称1，3-偶极加成反应，在温和的条件下高产率、高对映选择性地合成了多取代吡咯烷.
A Bronsted acid catalyzed three-component asymmetric 1,3-dipolar addition reaction between aldehydes, amino esters, and dipolarophiles by a new bisphosphoric acid, derived from the linked BINOL, furnished multiply substituted pyrrolidines in high yield with excellent enantioselectivities under mild conditions.