Effect of dietary medium- and long-chain triacylglycerols (MLCT) on accumulation of body fat in healthy humans.
Effect of dietary medium- and long-chain triacylglycerols (MLCT) on accumulation of body fat in healthy humans.
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DOI：
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发表时间：
2003
影响因子：
1.3
通讯作者：
M. Kasai;N. Nosaka;Hideaki Maki;S. Negishi;T. Aoyama;Masahiro Nakamura;Yoshie Suzuki;H. Tsuji-
中科院分区：
文献类型：
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作者：
M. Kasai;N. Nosaka;Hideaki Maki;S. Negishi;T. Aoyama;Masahiro Nakamura;Yoshie Suzuki;H. Tsuji-
我们研究了结构化中链和长链三酰甘油（MLCT）饮食是否可以减少健康人体内脂肪的积累。该研究是在双盲随机设计下进行的。九十三名受试者参与了这项研究。然而，有 10 名受试者无法食用指定的膳食，还有 1 名受试者希望选择退出。因此，该研究包括 82 名受试者。在为期 12 周的研究期间，实验对象每天早餐时食用由 14 克 MLCT（含 1.7 克 MCFA）制成的测试面包，而对照组则食用由长链三酰甘油（LCT）制成的面包。所有受试者都食用相同的标准包装膳食。身体成分参数包括体重、全身脂肪和腹部脂肪，血液分析包括血清胆固醇、三酰甘油和磷脂。 12周后MLCT组与LCT组相比体重、体脂量、皮下脂肪和内脏脂肪均显着下降（P<0.05）。此外，与LCT组相比，8周时MLCT组的血清总胆固醇显着降低（P<0.05）。然而，MLCT 组和 LCT 组之间的其他血清参数没有差异。结果表明，每天摄入MLCT饮食可以减少体重和体内脂肪的积累，而且还可以降低血清总胆固醇。
We investigated whether a structured medium- and long-chain triacylglycerols (MLCT) diet could decrease accumulation of body fat in healthy humans. The study was conducted under a double-blind randomized design. Ninety-three subjects participated in this study. However, 10 subjects could not consume the specified meal, and one subject wished to opt out. Consequently, the study included 82 subjects. The experimental subjects consumed the test bread, which was made with 14 g of MLCT containing 1.7 g MCFA, daily at breakfast during the study period of 12 weeks, and the control subjects consumed bread made with long-chain triacylglycerols (LCT). All subjects consumed the same standard packaged meals. Body composition parameters were body weight, total body fat and abdominal fat, and blood analyses included serum cholesterol, triacylglycerols and phospholipids. Significant decreases of body weight, the amount of body fat, subcutaneous and visceral fat were noted in the MLCT group as compared with those of the LCT group for 12 weeks (P<0.05). Furthermore, a significant decrease in serum total cholesterol was noted in the MLCT group as compared with that of the LCT group at 8 weeks (P<0.05). However, other serum parameters were not different between the MLCT and LCT groups. The results suggest that the daily intake of MLCT diet could result in a reduction in body weight and in accumulation of body fat, and, moreover, it could reduce serum total cholesterol.