Interpretations of 'appropriate' minority inclusion in clinical research
Interpretations of 'appropriate' minority inclusion in clinical research
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DOI：
10.1016/j.amjmed.2003.09.032
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发表时间：
2004-02-15
影响因子：
5.9
通讯作者：
Ransohoff, MF
中科院分区：
文献类型：
--
作者：
Corbie-Smith, G;Miller, WC;Ransohoff, MF
对“适当代表”一词的各种可能解释使调查人员难以实际应用国家卫生研究院关于将少数群体纳入研究的指导方针。将少数群体纳入临床研究至少可以达到三个目标：检验关于种族和族裔差异的具体假设;提出关于种族和族裔可能差异的假设;确保公平分配参与研究的利益和负担，无论种族或族裔的结果是否存在预期差异。在本文中，我们描述了对“适当代表”的可能解释，并提供了调查人员可能用来解决这一问题的一般方法。为了扩大关于少数群体健康的科学知识，研究人员应该说明他们选择了哪个目标，以及为什么与其他可能的目标相比，这个目标是适当的。(C)2004年，Excerpta Medica Inc.
The range of possible interpretations of the phrase "appropriate representation" has left investigators struggling with the practical application of the National Institutes of Health guidelines on the inclusion of minorities in research. At least three goals might be reached by including minorities in clinical research: to test specific hypotheses about differences by race and ethnicity; to generate hypotheses about possible differences by race and ethnicity; and to ensure the just distribution of the benefits and burdens of participation in research, regardless of whether there are expected differences in outcome by race or ethnicity. In this paper, we describe possible interpretations of "appropriate representation," as well as provide a general approach that investigators might use to address this issue. To expand scientific knowledge about the health of minority populations, investigators should be expected to state which goal they have selected and why that goal is appropriate as compared with other possible goals. (C) 2004 by Excerpta Medica Inc.