Evaluation of appendectomy as a potential risk factor for immune checkpoint inhibitor-associated enterocolitis.
Evaluation of appendectomy as a potential risk factor for immune checkpoint inhibitor-associated enterocolitis.
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评价阑尾切除术作为免疫检查点通道相关小肠结肠炎的潜在危险因素。
DOI：
10.2217/imt-2022-0245
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发表时间：
2023-06
期刊：
影响因子：
2.8
通讯作者：
N. Krasnow;D. Chute;A. S. Falade;C. North;K. Reynolds;M. Dougan
中科院分区：
文献类型：
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作者：
N. Krasnow;D. Chute;A. S. Falade;C. North;K. Reynolds;M. Dougan
目的：探讨阑尾切除术与免疫检查点抑制剂（ICI）小肠结肠炎之间的关系。方法：纳入 2010 年 7 月至 2020 年 9 月期间开始 ICI 的患者 (n = 10,907)。暴露组包括手术记录中在 ICI 之前有阑尾切除术证据的患者 (n = 380)。对照组包括放射学报告中阑尾正常证据的患者 (n = 3602)。 ICI 小肠结肠炎被定义为 ICI 引起的结肠炎或肠炎的组织病理学证据。阑尾切除术和 ICI 小肠结肠炎之间的关联通过多变量逻辑回归来表征。结果：248 名患者 (6.2%) 出现 ICI 小肠结肠炎。既往接受过阑尾切除术的患者和未接受过阑尾切除术的患者发生 ICI 小肠结肠炎的几率相似（调整后的比值比：0.82；95% CI：0.49-1.36；p = 0.449）。结论：未发现既往阑尾切除术与 ICI 小肠结肠炎之间存在关联。
Aims: The relationship between appendectomy and immune checkpoint inhibitor (ICI) enterocolitis was explored. Methods: Patients who began ICIs between July 2010 and September 2020 (n = 10,907) were included. The exposure group included patients with evidence of appendectomy prior to ICIs in operative notes (n = 380). The control group included patients with evidence of normal appendix in radiologic reports (n = 3602). ICI enterocolitis was defined as histopathologic evidence of colitis or enteritis attributed to ICIs. The association between appendectomy and ICI enterocolitis was characterized by multivariate logistic regression. Results: 248 patients (6.2%) developed ICI enterocolitis. The odds of ICI enterocolitis were similar among those with prior appendectomy and those without appendectomy (adjusted odds ratio: 0.82; 95% CI: 0.49-1.36; p = 0.449). Conclusion: No association was found between prior appendectomy and ICI enterocolitis.