Intramuscular Administration of Alfaxalone Alone and in Combination for Sedation and Anesthesia of Rabbits (Oryctolagus cuniculus)
Intramuscular Administration of Alfaxalone Alone and in Combination for Sedation and Anesthesia of Rabbits (Oryctolagus cuniculus)
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DOI：
10.30802/aalas-jaalas-18-000078
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发表时间：
2019-03-01
影响因子：
1.7
通讯作者：
Lester, Patrick A.
中科院分区：
文献类型：
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作者：
Bradley, Michael P.;Doerning, Carolyn M.;Lester, Patrick A.
这项研究比较了单独和与其他药物联合应用阿法克斯对新西兰大白兔肌肉注射后的镇静和麻醉特性。在研究的主要部分，6只雌性兔以盲法交叉设计被分配到5种治疗方案中。阿法松(6 mg/kg肌注)单独及与下列药物联合应用：0.3 mg/kg布托啡诺、1 mg/kg咪达唑仑、0.2 mg/kg右美托咪定、0.3 mg/kg布托啡诺和0.2 mg/kg右美托咪定。另有6只兔给予0.2 mg/kg右旋美托咪定作为对照。开始卧床的中位时间从2.0分钟到5.5分钟不等，接受阿法松和咪达唑仑或右美托咪定治疗的动物的时间明显短于只接受右美托咪啶治疗的动物。镇静时间(平均+/-1SD)为：单用阿法松，40±-7.3min；阿法松+布托啡诺，47.8±/-9.9min；阿法松+咪达唑仑，65.2±-6.5min；阿法松+右美托咪定，157.5±/-22.4min；阿法松+布托啡诺和右美托咪定，157.7+/-22.3min，单用右美托咪定，93.7±/-11.9min。2只给予右美托咪定的兔，4只给予阿法松加右美托咪定的兔，以及全部6只给予阿法松、布托啡诺和右美托咪定的兔，对伤害性刺激没有反应；最后一组表现出最长的脚趾夹痛反应(57+/-3分钟)。
This study compared alfaxalone, alone and in combination with other medications, for sedative and anesthetic properties after intramuscular administration in New Zealand white rabbits. In the main portion of the study, 6 female rabbits were assigned to 5 treatment regimens in a blinded crossover design. Alfaxalone (6 mg/kg IM) was administered alone and in combination with each of the following: 0.3 mg/kg butorphanol; 1 mg/kg midazolam; 0.2 mg/kg dexmedetomidine; and both 0.3 mg/kg butorphanol and 0.2 mg/kg dexmedetomidine. An additional 6 rabbits received 0.2 mg/kg dexmedetomidine for comparison. The median time to onset of recumbency ranged from 2.0 to 5.5 min, with times significantly shorter for animals that received alfaxalone with either midazolam or dexmedetomidine than for those given dexmedetomidine only. Duration of sedation (mean +/- 1 SD) was: alfaxalone only, 40 +/- 7.3 min; alfaxalone with butorphanol, 47.8 +/- 9.9 min; alfaxalone with midazolam, 65.2 +/- 6.5 min; alfaxalone with dexmedetomidine, 157.5 +/- 22.4 min; alfaxalone with butorphanol and dexmedetomidine, 157.7 +/- 22.3 min, and dexmedetomidine only, 93.7 +/- 11.9 min. Response to noxious stimuli was absent in 2 of the rabbits given dexmedetomidine only, 4 of those given alfaxalone with dexmedetomidine, and all 6 of the animals dosed with alfaxalone, butorphanol, and dexmedetomidine; this last group displayed the longest absence of a toe-pinch response (57 +/- 3 min).