Variations in three-dimensional cancellous bone architecture of the proximal femur in female hip fractures and in controls
Variations in three-dimensional cancellous bone architecture of the proximal femur in female hip fractures and in controls
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DOI：
10.1359/jbmr.2000.15.1.32
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发表时间：
2000-01-01
影响因子：
6.2
通讯作者：
Goldstein, SA
中科院分区：
文献类型：
--
作者：
Ciarelli, TE;Fyhrie, DP;Goldstein, SA
从女性髋部骨折（n = 26）和女性尸体对照（n = 32）的股骨近端取松质骨立方体，比较两组间的结构和力学。在微计算机断层扫描系统上扫描样品，应用立体算法和基于模型的估计对数据进行表征三维松质微观结构，对立方体进行机械测试以获得力学性能失败。对照组标本的骨体积分数、骨小梁数目和连通性明显高于髋部骨折患者标本；各组间骨小梁厚度无差异。对照组的最大模量和极限应力均明显高于骨折组，这与对照组较高的骨体积一致。当两组骨量相匹配时，没有发现任何这些建筑或机械变量的统计差异。髋部骨折患者和对照组的标本均显示骨小梁数目和骨体积分数之间有很强的相关性，且在统计学上相等，这表明对于给定的骨量，两组的骨小梁总数相同，但骨折组与对照组在骨小梁的三维空间排列方面存在结构上的差异。骨折标本的各向异性（定向）结构明显高于对照标本，即使在匹配骨体积的情况下，横向的小梁元件也相对较少。力学和建筑参数之间的关系在各组之间存在显著差异，表明骨折组和对照组具有不同的结构-力学关系，我们假设这可能是组间三维结构改变的结果。
Cubes of cancellous bone were obtained from proximal femora of women with hip fractures (n = 26) and from female cadaveric controls (n = 32) to compare architecture and mechanics between groups. Specimens were scanned on a microcomputed tomography system, Stereologic algorithms and model-based estimates were applied to the data to characterize the three-dimensional cancellous microstructure, Cubes were mechanically tested to failure to obtain mechanical properties. Specimens from control subjects had significantly higher bone volume fraction, trabecular number, and connectivity than specimens from patients with hip fractures; no difference in trabecular thickness was observed between groups. Both maximum modulus and ultimate stress were significantly higher in the control than in the fracture group, consistent with the higher bone volume found in the control group. No statistical differences in any of these architectural or mechanical variables were found when groups were matched for bone volume. Specimens from both patients with hip fractures and controls demonstrated strong relationships between trabecular number and bone volume fraction that were statistically equivalent, suggesting that fur a given bone mass, both groups have the same overall number of trabeculae, However, there was an architectural difference between fracture and control groups in terms of the three-dimensional spatial arrangement of trabeculae, Fracture specimens had a significantly more anisotropic (oriented) structure than control specimens, with proportionately fewer trabecular elements transverse to the primary load aids, even when matched for bone volume. Relationships between mechanical and architectural parameters were significantly different between groups, suggesting that fracture and control groups have different structure-mechanics relationships, which we hypothesize may be a consequence of the altered three-dimensional structure between groups.