Dihydroartemisinin induces autophagy by suppressing NF-κB activation
Dihydroartemisinin induces autophagy by suppressing NF-κB activation
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DOI：
10.1016/j.canlet.2013.09.035
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发表时间：
2014-02-28
期刊：
影响因子：
9.7
通讯作者：
Zhou, Hui-Jun
中科院分区：
文献类型：
--
作者：
Hu, Wei;Chen, Sang-Sang;Zhou, Hui-Jun
核因子-kappaB(NF-kappa B)和自噬是肿瘤发生和发展的两个主要调节因子。然而，这两条信号通路之间的联系仍然不清楚。在这项工作中，我们证明了双氢青蒿素(DNA)通过抑制核因子-kappaB的活性来刺激几种癌细胞株的自噬诱导。我们还表明，抑制核因子-kappa B会导致活性氧物种(ROS)的积累，这参与了自噬的刺激。这些发现提供了一条DHA促进癌细胞自噬的途径，并为DHA诱导某些化疗药物的增敏作用提供了证据。(C)2013爱思唯尔爱尔兰有限公司。保留所有权利。
Nuclear factor-kappa B (NF-kappa B) and autophagy are two major regulators involved in both tumor initiation and progression. However, the association between these two signaling pathways still remains obscure. In this work, we demonstrate that dihydroartemisinin (DNA) stimulates the induction of autophagy in several cancer cell lines through repression of NF-kappa B activity. We also show that inhibiting NF-kappa B results in an accumulation of reactive oxygen species (ROS), which participate in the stimulation of autophagy. These findings present a pathway by which DHA promotes autophagy in cancer cells and provide evidence for the DHA-induced sensitization effect of some chemotherapeutics. (C) 2013 Elsevier Ireland Ltd. All rights reserved.