Functional topography of the secondary somatosensory cortex for nonpainful and painful stimulation of median and tibial nerve: an fMRI study
Functional topography of the secondary somatosensory cortex for nonpainful and painful stimulation of median and tibial nerve: an fMRI study
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DOI：
10.1016/j.neuroimage.2004.08.003
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发表时间：
2004-11-01
期刊：
影响因子：
5.7
通讯作者：
Roman, GL
中科院分区：
文献类型：
--
作者：
Ferretti, A;Del Gratta, C;Roman, GL
功能性磁共振成像（fMRI）用于研究正中神经和胫神经的非疼痛（运动阈值）和疼痛电刺激期间双侧次级体感皮层（SII）的皮层活动。对八名正常年轻人进行了功能磁共振成像记录。目的是评估非疼痛和疼痛人群的空间隔离的工作假设，不仅在 SII 的“手”表示中 [Ferretti, A., Babiloni, C., Del Gratta, C., Caulo, M., Tartaro, A., Bonomo, L., Rossini, P.M., Romani, G.L., 2003。 次级体感皮层的非疼痛和疼痛功能拓扑刺激：功能磁共振成像研究。 NeuroImage 20, 16251638.1 以及其“脚”表示。结果表明，在双侧 SII 的“手”和“脚”表示中，由疼痛刺激引起的活动相对于由非疼痛刺激引起的活动定位得更靠后。对 Sit 反应的精细空间分析揭示了双侧 Sit 分区中清晰的躯体组织，尤其对非疼痛刺激有反应（即，手和脚表征的分离）相反，不可能将 SII 的疼痛刺激的“手”和“脚”表征分离出来。这些结果延伸到了 SII“手”表征中疼痛和非疼痛刺激的空间分离的先前证据。根据 1.5 T 的 fMRI 数据推断。(C) 2004 Elsevier Inc. 保留所有权利。
Functional magnetic resonance imaging (fMRI) was used to study the cortical activity of the bilateral secondary somatosensory cortex (SII) during nonpainful (motor threshold) and painful electrical stimulation of median and tibial nerves. fMRI recordings were performed in eight normal young adults. The aim was at evaluating the working hypothesis of a spatial segregation of nonpainful and painful populations not only in the "hand" representation of SII [Ferretti, A., Babiloni, C., Del Gratta, C., Caulo, M., Tartaro, A., Bonomo, L., Rossini, P.M., Romani, G.L., 2003. Functional topography of the secondary somatosensory cortex for nonpainful and painful stimuli: an fMRI study. Neurolmage 20, 16251638.1 but also in its "foot'' representation. Results showed that, in both "hand'' and "foot'' representations of bilateral SII, the activity elicited by the painful stimulation was localized more posteriorly with respect to that elicited by the nonpainful stimulation. A fine spatial analysis of the Sit responses revealed a clear somatotopic organization in the bilateral Sit subregion especially reactive to the nonpainful stimuli (i.e., segregation of the hand and foot representations). In contrast, it was not possible to disentangle the "hand" and "foot" representations of SII for painful stimuli. These results extended to the SII "foot" representation previous evidence of a spatial segregation in the SII "hand" representation of subregions for the painful and nonpainful stimuli. Furthermore, they suggest that noxious information is not somatotopically represented in human bilateral SII, at least as inferred from fMRI data at 1.5 T. (C) 2004 Elsevier Inc. All rights reserved.