Delayed remission after thymectomy for myasthenia gravis of the purely ocular type
Delayed remission after thymectomy for myasthenia gravis of the purely ocular type
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DOI：
10.1016/s0022-5223(96)70264-7
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发表时间：
1996-08-01
影响因子：
6
通讯作者：
Mori, T
中科院分区：
文献类型：
--
作者：
Nakamura, H;Taniguchi, Y;Mori, T
本文回顾了22例单纯眼肌型重症肌无力患者的胸腺切除术。缓解率随时间逐渐增加（3年为11.8%，5年为23.1%，10年为33.3%）。影响缓解时间的因素分析表明。病程短的患者明显更早达到缓解（5年随访时p = 0.035），22例单纯眼肌型重症肌无力患者中有1例（4.5%）出现疾病进展。由于眼肌型重症肌无力常发展为全身型，而术前病程是影响病情缓解的重要因素之一，因此，与全身型重症肌无力一样，眼肌型重症肌无力的早期治疗应首选胸腺切除术。
Twenty-two cases of purely ocular myasthenia gravis were reviewed to evaluate the long-term effects of thymectomy. Remission rate increased gradually with time (11.8% at 3 years, 23.1% at 5 years, and 33.3% at 10 years). Analysis of factors influencing remission with time showed that. patients with short duration of illness attained remission significantly earlier (p = 0.035 at 5-year follow-up), One of 22 patients with purely ocular myasthenia gravis (4.5%) had disease progression. Because ocular myasthenia gravis often progresses to the generalized type and because duration of illness before operation is one of important factors influencing remission, we conclude that thymectomy in the earlier stages of the disease is the preferred treatment for ocular myasthenia gravis, just as for generalized myasthenia gravis.