STUDIES ON CARRAGEENAN-INDUCED ARTHRITIS IN ADULT-RATS - PRESENCE OF NERVE GROWTH-FACTOR AND ROLE OF SYMPATHETIC INNERVATION
STUDIES ON CARRAGEENAN-INDUCED ARTHRITIS IN ADULT-RATS - PRESENCE OF NERVE GROWTH-FACTOR AND ROLE OF SYMPATHETIC INNERVATION
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DOI：
10.1007/bf00302155
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发表时间：
1992-11-01
影响因子：
4
通讯作者：
LEVIMONTALCINI, R
中科院分区：
文献类型：
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作者：
ALOE, L;TUVERI, MA;LEVIMONTALCINI, R
我们研究所最近的研究表明，各种形式的人类关节炎在滑膜中表达化学和生物活性的神经生长因子（NGF）。在本研究中，我们使用角叉菜胶诱导的关节炎模型来进一步评估关节炎症对NGF水平的影响。这些研究表明，实验诱导的大鼠关节炎导致滑膜血管周围区域的NGF显著增加。我们还表明，注射到滑膜中的纯化的NGF本身并不引起炎症，周围交感神经支配的破坏显着降低了炎症和注射角叉菜胶后的NGF水平。
Recent studies effected by our Institute indicate that various forms of human arthritis express both immunohistochemically and biologically active nerve growth factor (NGF) in the synovium. In the present study, we used a model of carrageenan-induced arthritis to further evaluate the effects of joint inflammation on NGF level. These studies showed that experimentally-induced arthritis in rats caused a significant increase in NGF in the perivascular area of the synovium. We also showed that injection into the synovium of purified NGF did not cause inflammation per se and that the destruction of peripheral sympathetic innervation significantly reduced both the inflammation and the level of NGF following carrageenan injection.