A correlativity study of plasma APL1β28 and clusterin levels with MMSE/MoCA/CASI in aMCI patients.
A correlativity study of plasma APL1β28 and clusterin levels with MMSE/MoCA/CASI in aMCI patients.
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DOI：
10.1038/srep15546
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发表时间：
2015-10-27
影响因子：
4.6
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Meng Y;Li H;Hua R;Wang H;Lu J;Yu X;Zhang C
遗忘型轻度认知障碍（aMCI）是一种亚临床病症，其特征在于记忆缺陷不足以影响日常功能。在此，我们研究了在AD患者脑脊液中发现的两种潜在生物标志物，APLP 1衍生的Aβ样肽28（APL 1 β28）和clusterin血浆水平与认知功能的关系，如aMCI患者的简易精神状态检查（MMSE）、蒙特利尔认知评估（莫卡）和认知评估筛选工具（CASI）所反映的。本研究招募了47名aMCI患者和35名年龄和性别匹配的健康成人对照。采用ELISA方法检测aMCI患者和对照组APL 1 β28和clusterin的平均浓度，结果发现aMCI患者和对照组APL 1 β28和clusterin的平均浓度无显著性差异。aMCI患者APL 1 β28与clusterin呈正相关，与MMSE评分呈负相关。aMCI患者的莫卡和CASI评分与白藜芦醇水平呈负相关。多因素分析显示，clusterin与MMSE/莫卡/CASI的相关性与年龄、性别、受教育程度、体重指数、ApoE基因型等AD危险因素无关。本文提供的数据表明，血浆聚集蛋白水平反映了aMCI患者的认知功能。
Amnestic mild cognitive impairment (aMCI) is a sub-clinical condition characterized by memory deficits that are not severe enough to affect daily functioning. Here we investigated two potential biomarkers found in the cerebrospinal fluid of AD patients, APLP1-derived Aβ-like peptides 28 (APL1β28) and clusterin plasma levels, in terms of their relationship to cognitive function, as reflected in the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA) and the Cognitive Assessment Screening Instrument (CASI) in aMCI patients. Forty-seven aMCI patients and thirty-five age- and gender-matched healthy adult controls were recruited for this study. Using the ELISA method, we found that the mean concentrations of both APL1β28 and clusterin were not significantly different between the control and aMCI groups. The APL1β28 levels were positively correlated with clusterin and that both were negatively correlated with the MMSE scores of the aMCI patients. Clusterin levels were negatively correlated with the MoCA and CASI scores of the aMCI patients. Using multivariate analysis, the correlation between clusterin and MMSE/MoCA/CASI was independent of other AD risk factors including age, education, sex, body mass index and ApoE genotype. The data presented here demonstrate that plasma clusterin levels reflect cognitive function in aMCI patients.