The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia
The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia
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DOI：
10.1002/ajmg.b.31123
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发表时间：
2010-12-01
影响因子：
2.8
通讯作者：
Takeda, Masatoshi
中科院分区：
文献类型：
--
作者：
Hashimoto, Ryota;Ohi, Kazutaka;Takeda, Masatoshi
最近的一项全基因组关联研究表明，ZNF 804A基因的一个变体（rs1344706）与精神分裂症和双相情感障碍有关。复制研究支持ZNF804A基因中的这种变异与精神分裂症之间的关联，并且这种变异是最可能的易感性变异。随后在健康受试者中进行的功能性磁共振成像研究表明，在记忆任务和心理理论任务期间，高风险ZNF 804A变体与神经激活相关。由于这些认知表现在精神分裂症患者中受到干扰，该基因可能在精神分裂症的认知功能障碍中发挥作用。本研究的目的是探讨ZNF 804A多态性与记忆功能之间的潜在关系。采用双因素协方差分析方法，对113例精神分裂症患者和184例健康对照者的语言记忆、视觉记忆（VisM）、注意力/集中和延迟回忆（用韦氏记忆量表修订版测量）进行了分析。与既往研究一致，精神分裂症患者的所有指标均低于健康对照受试者（P0.05）。我们的数据表明，rs1344706可能与精神分裂症的记忆功能障碍。(C)2010 Wiley-Liss，Inc.
A recent genome-wide association study showed that a variant (rs1344706) in the ZNF804A gene was associated with schizophrenia and bipolar disorder. Replication studies supported the evidence for association between this variant in the ZNF804A gene and schizophrenia and that this variant is the most likely susceptibility variant. Subsequent functional magnetic resonance imaging studies in healthy subjects demonstrated the association of the high-risk ZNF804A variant with neural activation during a memory task and a theory of mind task. As these cognitive performances are disturbed in patients with schizophrenia, this gene may play a role in cognitive dysfunction in schizophrenia. The aim of the current study was to investigate the potential relationship between this ZNF804A polymorphism and memory function. The effects of the high-risk ZNF804A genotype, diagnosis, and genotype-diagnosis interaction on verbal memory, visual memory (VisM), attention/concentration, and delayed recall (measured by the Wechsler Memory Scale-Revised) were analyzed by two-way analysis of covariance in 113 patients with schizophrenia and 184 healthy subjects. Consistent with previous studies, patients with schizophrenia exhibited poorer performance on all indices as compared to healthy control subjects (P0.05). Our data suggest that rs1344706 may be related to memory dysfunction in schizophrenia. (C) 2010 Wiley-Liss, Inc.