Cardiovascular risk factors clustering features of insulin resistance syndrome (Syndrome X) in a biracial (Black-White) population of children, adolescents, and young adults: the Bogalusa Heart Study.
Cardiovascular risk factors clustering features of insulin resistance syndrome (Syndrome X) in a biracial (Black-White) population of children, adolescents, and young adults: the Bogalusa Heart Study.
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DOI：
10.1093/oxfordjournals.aje.a010069
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发表时间：
1999-10
影响因子：
5
通讯作者：
Wei Chen;S. Srinivasan;Abdalla Elkasabany;G. Berenson
中科院分区：
文献类型：
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作者：
Wei Chen;S. Srinivasan;Abdalla Elkasabany;G. Berenson
近年来，通过因子分析在中老年人群中发现了代表胰岛素抵抗综合征（X综合征）不同特征的独立因素。在这项研究中，对1988-1996年间Bogalusa心脏研究筛选的4,522名儿童（5-11岁）、青少年（12-17岁）和年轻人（18-38岁）的社区双种族（黑白）人群中的X综合征的聚类特征进行了因子分析。Ponderal指数(体重（kg)/身高(m)3）、胰岛素、葡萄糖、甘油三酯和高密度脂蛋白胆固醇水平以及收缩压和舒张压被用来衡量x综合征的组成部分。没有证据支持该综合征的单因素假设，但因素分析得出了两个不相关的因素（因素1：胰岛素/脂/葡萄糖/ Ponderal指数；因素2：胰岛素/血压）。这两个因素解释了整个样本中54.6%的总方差。因子负荷模式在所有种族和年龄组中非常相似，基于高值的同余系数（0.89-1.0）。这些结果表明，X综合征的特征是代谢实体（高胰岛素血症/胰岛素抵抗、血脂异常和肥胖）与血液动力学因素（高血压）通过与高胰岛素血症/胰岛素抵抗的共同相关性联系在一起，并且在黑人和白人人群中，聚类特征与性别和年龄无关。
Recently, independent factors representing different features of insulin resistance syndrome (Syndrome X) have been identified by factor analysis in middle-aged and elderly adult populations. In this study, factor analysis was applied to the clustering characteristics of Syndrome X in a biracial (Black-White) community-based population of 4,522 children (ages 5-11 years), adolescents (ages 12-17 years), and young adults (ages 18-38 years) from the Bogalusa Heart Study who were screened during 1988-1996. Ponderal index (weight (kg)/height (m)3), levels of insulin, glucose, triglycerides, and high density lipoprotein cholesterol, and systolic and diastolic blood pressure were used as measures of components of Syndrome X. No evidence was found to support a one-factor hypothesis for this syndrome, but factor analysis yielded two uncorrelated factors (factor 1: insulin/lipids/glucose/ponderal index; factor 2: insulin/blood pressure). These two factors explained 54.6% of the total variance in the entire sample. The factor loading patterns were very similar in all race and age groups, based on high values of coefficients of congruence (0.89-1.0). These results suggest that Syndrome X is characterized by the linking of a metabolic entity (hyperinsulinemia/insulin resistance, dyslipidemia, and obesity) to a hemodynamic factor (hypertension) through shared correlation with hyperinsulinemia/insulin resistance, and that the clustering features are independent of sex and age in both Black and White populations.