SELECTIVE OXIDATION OF MONOSACCHARIDE DERIVATIVES TO URONIC-ACIDS
SELECTIVE OXIDATION OF MONOSACCHARIDE DERIVATIVES TO URONIC-ACIDS
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DOI：
10.1016/s0040-4039(00)77522-8
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发表时间：
1993-02-12
影响因子：
1.8
通讯作者：
FLITSCH, SL
中科院分区：
文献类型：
--
作者：
DAVIS, NJ;FLITSCH, SL
在催化量的2，2，6，6-四甲基-1-哌啶基氧自由基（克里思）存在下，用次氯酸钠将部分保护的单糖衍生物中的伯羟基选择性氧化成羧酸。缩醛、苄基和酰基保护基团在氧化反应期间不受影响。
Primary hydroxyl groups in partially protected monosaccharide derivatives were selectively oxidised to carboxylic acids using sodium hypochlorite in the presence of catalytic amounts of 2,2,6,6-tetramethyl-1-piperidinyl oxy, free radical (TEMPO). Acetal, benzyl and acyl- protection groups were unaffected during the oxidation reaction.