The role of apelin-13 in novel object recognition memory
The role of apelin-13 in novel object recognition memory
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apelin-13 在新物体识别记忆中的作用
DOI：
10.1016/j.peptides.2014.10.003
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发表时间：
2014-12-01
期刊：
影响因子：
3
通讯作者：
Wang, Rui
中科院分区：
文献类型：
--
作者：
Han, Ren-wen;Xu, Hong-jiao;Wang, Rui
爱帕琳及其受体APJ（爱帕琳受体）在参与学习和记忆的脑区域中显著表达。然而，apelin在认知中的作用在很大程度上尚不清楚。在此，在小鼠新物体识别任务中研究了爱帕琳-13在记忆过程中的作用。训练后注射apelin-13（0.3和1 nmol）剂量依赖性地损害短期记忆（STM），然而，训练前输注apelin-13（1 nmol）不影响STM，表明apelin-13阻断STM的形成，但不获得STM。立即、训练后30、60或120分钟给予的爱帕琳-13（1 nmol）以时间依赖性方式（30分钟）损害长期记忆（LTM），然而，训练前和测试前输注爱帕琳-13（1 nmol）均不影响LTM，表明爱帕琳-13损害巩固，但不损害LTM的获得和回忆。综上所述，我们的研究结果首次表明，apelin-13阻断了新物体识别任务中的STM形成和LTM巩固。(C)2014 Elsevier Inc. All rights reserved.
Apelin and its receptor APJ (apelin receptor) are prominently expressed in brain regions involved in learning and memory. However, the role of apelin in cognition was largely unclear. Here, the role of apelin-13 in memory processes was investigated in mice novel object recognition task. Post-training injection of apelin-13 (0.3 and 1 nmol) dose-dependently impaired short-term memory (STM), however, pre-training infusion of apelin-13 (1 nmol) did not affect STM, suggesting apelin-13 blocks formation but not acquisition of STM. Apelin-13 (1 nmol) administered immediately, 30, 60 or 120 min post-training impaired long-term memory (LTM) in a time-dependent manner (30 min), however, both pre-training and pre-test infusion of apelin-13 (1 nmol) did not affect LTM, suggesting apelin-13 impaired consolidation but not acquisition and recall of LTM. Taken together, for the first time, our results indicate that apelin-13 blocks STM formation and LTM consolidation in novel object recognition task. (C) 2014 Elsevier Inc. All rights reserved.