Isotopic enrichment enhancement in metabonomic analysis of UPLC-MS data sets
Isotopic enrichment enhancement in metabonomic analysis of UPLC-MS data sets
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DOI：
10.1002/jlcr.1217
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发表时间：
2007-04-01
影响因子：
1.8
通讯作者：
Wilson, Ian D.
中科院分区：
文献类型：
--
作者：
Athersuch, Toby J.;Nicholson, Jeremy K.;Wilson, Ian D.
在药物代谢研究中，化合物的同位素富集极大地增强了外源代谢物和内源代谢物的光谱区分。我们展示了(CN)-C-13-N-15标记模型药物（4-氰苯胺）的应用，以辅助uplc - ms生成的代谢数据集的代谢组学研究。版权所有(c) 2007约翰威利父子有限公司
Isotopic enrichment of compounds dosed in drug metabolism studies greatly enhances the spectroscopic differentiation of xenobiotic and endogenous metabolites. We show the application of (CN)-C-13-N-15 labelling of a model drug (4-cyanoaniline) as an aid to metabonomic studies of UPLC-MS-generated metabolic data sets. Copyright (c) 2007 John Wiley & Sons, Ltd.