Clinical aspects of neurointestinal disease: Pathophysiology, diagnosis, and treatment
Clinical aspects of neurointestinal disease: Pathophysiology, diagnosis, and treatment
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DOI：
10.1016/j.ydbio.2016.03.032
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发表时间：
2016-09-15
影响因子：
2.7
通讯作者：
De Giorgio, Roberto
中科院分区：
文献类型：
--
作者：
Goldstein, Allan M.;Thapar, Nikhil;De Giorgio, Roberto
肠神经系统（ENS）几乎参与了所有肠道功能的调节。肠内神经性疾病是多种机制的结果，包括影响ens结构和功能完整性的肠内神经元的异常发育、变性或丧失。在过去的十年中，临床和分子研究使我们对这些疾病的发病机制的认识取得了重要的概念进展。在这篇综述中，我们从临床角度考虑ENS疾病，并强调了关于其病理生理学的先进知识。我们还回顾了目前治疗这些疾病的方法，并提出了治疗这些疾病的潜在的新型修复方法。(C) 2016 Elsevier Inc.版权所有。
The enteric nervous system (ENS) is involved in the regulation of virtually all gut functions. Conditions referred to as enteric neuropathies are the result of various mechanisms including abnormal development, degeneration or loss of enteric neurons that affect the structure and functional integrity of the ENS. In the past decade, clinical and molecular research has led to important conceptual advances in our knowledge of the pathogenetic mechanisms of these disorders. In this review we consider ENS disorders from a clinical perspective and highlight the advancing knowledge regarding their pathophysiology. We also review current therapies for these diseases and present potential novel reparative approaches for their treatment. (C) 2016 Elsevier Inc. All rights reserved.