Frequencies of KIT and PDGFRA mutations in the MolecGIST prospective population-based study differ from those of advanced GISTs
Frequencies of KIT and PDGFRA mutations in the MolecGIST prospective population-based study differ from those of advanced GISTs
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DOI：
10.1007/s12032-011-0074-y
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发表时间：
2012-09-01
期刊：
影响因子：
3.4
通讯作者：
Aegerter, P.
中科院分区：
文献类型：
--
作者：
Emile, J. F.;Brahimi, S.;Aegerter, P.
胃肠道间质瘤（GIST）是最常见的人类肉瘤。大多数关于GIST的数据来自于对肿瘤中心患者的回顾性研究。MolecGIST研究试图确定GIST的临床病理学和分子特征并将其关联起来。前瞻性获得并审查了24个月期间在法国诊断的患者的肿瘤样本和临床记录。纳入596例患者，其中10%有同步转移。GIST起源于胃、小肠或其他部位的病例分别占56.4%、30.2%和13.4%。主要预后指标肿瘤的部位、大小和核分裂指数不是独立变量（P
Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma. Most of the data available on GISTs derive from retrospective studies of patients referred to oncology centers. The MolecGIST study sought to determine and correlate clinicopathological and molecular characteristics of GISTs. Tumor samples and clinical records were prospectively obtained and reviewed for patients diagnosed in France during a 24-month period. Five hundred and ninety-six patients were included, of whom 10% had synchronous metastases. GISTs originated from the stomach, small bowel or other site in 56.4, 30.2 and 13.4% of cases, respectively. The main prognostic markers, tumor localization, size and mitotic index were not independent variables (P