Collagen alpha B chain: increased proportion in human atherosclerosis.
Collagen alpha B chain: increased proportion in human atherosclerosis.
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胶原蛋白αB链：在人体动脉粥样硬化中比例增加。
DOI：
10.1126/science.7256267
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发表时间：
1981
期刊：
影响因子：
56.9
通讯作者：
A. Ooshima
中科院分区：
文献类型：
--
作者：
A. Ooshima
在一项针对人类动脉粥样硬化斑块的研究中，通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳估算了来自 28 个人主动脉的胃蛋白酶溶解的胶原蛋白中 α 链的相对丰度。与非硬化完整中膜和外膜相比，动脉粥样硬化斑块中 α B（V 型胶原中 α 链的组成部分）与 α 1(I) 的比率显着增加。提示在人体动脉粥样硬化形成过程中，硬化病变处增殖的平滑肌细胞发生转化，合成大量的胶原αB链。
In a study of human atherosclerotic plaques, the relative abundance of alpha chains in pepsin-solubilized collagens from 28 human aortas was estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The ratio of alpha B, a component of the alpha chain in type V collagen, to alpha 1(I) was markedly increased in the atherosclerotic plaques compared to the nonsclerotic intact media and adventitia. It is suggested that proliferating smooth muscle cells in the sclerotic lesion were transformed to synthesize a larger amount of collagen alpha B chain during the process of human atherogenesis.