Genetic variation in the vaspin gene affects circulating serum vaspin concentrations
Genetic variation in the vaspin gene affects circulating serum vaspin concentrations
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DOI：
10.1038/ijo.2012.133
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发表时间：
2013-06-01
影响因子：
4.9
通讯作者：
Stumvoll, M.
中科院分区：
文献类型：
--
作者：
Breitfeld, J.;Toenjes, A.;Stumvoll, M.
目的：内脏脂肪组织衍生丝氨酸蛋白酶抑制物(Vaspin)是一种脂肪因子，可能与肥胖、胰岛素抵抗和2型糖尿病有关。在这里，我们寻找可以解释血清vaspin浓度变异性的遗传决定因素。研究设计和方法：首先，我们在Sorbs队列(N=826)中进行了一项关于血清vaspin的全基因组关联研究。随后，对覆盖vaspin基因座遗传变异的26个单核苷酸多态(SNPs)进行了基因分型。此外，我们测量了来自奥格斯堡/奥格斯堡地区合作卫生研究(KORA)的1806个样本的血清vaspin浓度，以复制关联信号。结果：SERPINA1与SERPINA4在14号染色体上的6个SNPs定位均达到P值
OBJECTIVE: Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an adipokine potentially linking obesity, insulin resistance and type 2 diabetes. Here, we searched for genetic determinants that could explain the variability in serum vaspin concentrations.RESEARCH DESIGN AND METHODS: First, we conducted a genome-wide association study (GWAS) for serum vaspin in the Sorbs cohort (N = 826). Subsequently, 26 single-nucleotide polymorphisms (SNPs) covering genetic variation in the vaspin locus were genotyped in the Sorbs. In addition, we measured serum vaspin concentrations in 1806 samples from Augsburg/the Cooperative Health Research in the Region of Augsburg (KORA) for replication of the association signals. Finally, we conducted association analyses of vaspin SNPs with metabolic traits in the Sorbs (N = 1013), KORA (N = 1813) and a further cohort from Germany (Leipzig: N = 1857).RESULTS: Six SNPs mapping between serpinA1 and serpinA4, including the vaspin locus, on chromosome 14 reached P-values