Selective accumulation of hybrid liposomes into adult T-cell leukemia cells along with induction of apoptosis
Selective accumulation of hybrid liposomes into adult T-cell leukemia cells along with induction of apoptosis
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DOI：
10.1016/j.bmcl.2011.05.015
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发表时间：
2011-07-01
影响因子：
2.7
通讯作者：
Ueoka, Ryuichi
中科院分区：
文献类型：
--
作者：
Komizu, Yuji;Yukihara, Mamiko;Ueoka, Ryuichi
首次获得了90 mol% L-α-二肉豆蔻酰磷脂酰胆碱（DMPC）和10 mol%聚氧乙烯（n）十二烷基醚组成的混合脂质体（HL-n）对成人T细胞白血病细胞生长的显着抑制作用。值得注意的是，HL-n可以选择性地积累到成体T细胞白血病细胞中，并通过caspase-3激活诱导细胞凋亡。 (C) 2011 Elsevier Ltd. 保留所有权利。
Markedly inhibitory effects of hybrid liposomes (HL-n) composed of 90 mol % L-alpha-dimyristoylphosphatidylcholine (DMPC) and 10 mol % polyoxyethylene(n) dodecyl ethers on the growth of adult T-cell leukemia cells were obtained for the first time. It is noteworthy that HL-n could selectively accumulate into the adult T-cell leukemia cells and induce apoptosis via caspase-3 activation. (C) 2011 Elsevier Ltd. All rights reserved.