Lymph node topography of the head and neck in New Zealand White rabbits
Lymph node topography of the head and neck in New Zealand White rabbits
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DOI：
10.1258/002367703762226674
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发表时间：
2003-01-01
影响因子：
2.4
通讯作者：
Werner, JA
中科院分区：
文献类型：
--
作者：
Dunne, AA;Plehn, S;Werner, JA
研究新西兰白兔VX2癌的淋巴转移扩散需要准确了解颈部和面部淋巴结的形态。从大体、组织学和淋巴造影的角度观察了16只兔颈淋巴结的形态，并探讨了其手术切除(颈清扫术)的可能性。新西兰大白兔的上消化道和耳朵通过4组一致的12-18个淋巴结组进行引流。除气管旁淋巴结外，其他部位均可接受手术。这项研究提供的数据鼓励使用新西兰大白兔诱发的VX2癌作为动物模型来研究头颈部鳞状细胞癌的淋巴转移扩散。这样的研究可能导致这种肿瘤实体的外科和药物治疗的改进。
Investigations of the lymphogenic metastatic spread of VX2 carcinomas in New Zealand White rabbits require an exact knowledge of the topography of cervical and facial lymph nodes. The topography of neck lymph nodes was evaluated from 16 rabbits macroscopically, histologically and by lymphographic investigations, and the possibility of their surgical removal (neck dissection) was examined. The upper acrodigestive tract and the ear of New Zealand White rabbits drain via four consistent groups of 12-18 lymph nodes. Except for the paratracheal lymph node, they are all easily accessible to surgery. The data presented in this study encourage the use of induced VX2 carcinomas in New Zealand White rabbits as an animal model to study the lymphogenic metastatic spread of squamous cell carcinomas of the head and neck. Such investigations could lead to an improvement of surgical and pharmaceutical treatment of this tumour entity.