Neurological features of COVID-19 and their treatment: a review.
Neurological features of COVID-19 and their treatment: a review.
复制标题
DOI：
10.7573/dic.2020-5-1
复制
发表时间：
2020-01-01
期刊：
影响因子：
--
通讯作者：
Vista, Marco
中科院分区：
文献类型：
--
作者：
Orsucci, Daniele;Ienco, Elena Caldarazzo;Vista, Marco
严重急性呼吸综合征相关新型冠状病毒（SARS-Cov-2）感染可通过不同机制导致神经系统体征和症状。虽然中枢神经系统的直接感染不确定或非常罕见，并且感染相关并发症（例如炎性神经病）罕见，但谵妄和脓毒性脑病在重症患者中很常见。轻度病例中，尤其是年轻人和女性，脑功能障碍和头痛非常常见。肌肉疼痛在轻度和重度病例中都很常见，在大多数受损患者中，它伴随着肌酸激酶水平升高和可能的真正肌病损伤。缺血性卒中已被报道为与严重SARS-Cov-2感染相关的高凝状态的可能并发症，但需要进一步研究。大多数神经系统表现可能发生在疾病的早期。因此，在大流行期间，神经科医生需要参与，警惕和准备。在疫苗问世之前，神经病学的实践将不会相同。
Severe acute respiratory syndrome-correlated new coronavirus (SARS-Cov-2) infection may result in neurological signs and symptoms through different mechanisms. Although direct infection of the central nervous system is uncertain or very rare and the para-infectious complications (e.g. inflammatory neuropathies) are rare, delirium and septic encephalopathy are common in severely ill patients. Smell dysfunction and headache are very common in mild cases, especially in younger people and females. Muscle pain is common in both mild and severe cases, and in the most compromised patients, it is accompanied by increased creatine kinase levels and by a likely true myopathic damage. Ischemic stroke has been reported as a possible complication of the hypercoagulability associated with severe SARS-Cov-2 infection, but further studies are needed. Most of the neurological manifestations may occur early in the illness. Therefore, during the pandemic period, neurologists need to be involved, alert, and prepared. Neurological practice will not be the same until a vaccine is available.