Controlled release of drug from folate-decorated and graphene mediated drug delivery system: Synthesis, loading efficiency, and drug release response
Controlled release of drug from folate-decorated and graphene mediated drug delivery system: Synthesis, loading efficiency, and drug release response
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DOI：
10.1016/j.msec.2011.04.010
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发表时间：
2011-10-10
影响因子：
7.9
通讯作者：
Misra, R. D. K.
中科院分区：
文献类型：
--
作者：
Depan, D.;Shah, J.;Misra, R. D. K.
制备了一种新型叶酸修饰的石墨烯介导的药物递送系统，其涉及独特地将氧化石墨烯（GO）与抗癌药物结合以控制药物释放。纳米载体系统是通过将多柔比星（DOX）经由强π-π堆积相互作用连接到氧化石墨烯，然后用叶酸缀合的壳聚糖包封氧化石墨烯来合成的。简化为非共价型官能化的π-π堆积相互作用能够实现高药物负载和随后的药物控释。由于壳聚糖的亲水性和阳离子性质，包封的氧化石墨烯增强了纳米载体系统在水介质中的稳定性。DOX的负载和释放表明强烈的pH依赖性，并暗示氧化石墨烯和DOX之间的氢键相互作用。所提出的策略在靶向药物递送方面是有利的，并且具有解决药物递送中的当前挑战的高潜力。因此，所制备的纳米混合系统提供了一种新的配方，该配方结合了生物可降解材料、壳聚糖和氧化石墨烯的独特性能，用于生物医学应用。(C)2011 Elsevier B. V.保留所有权利。
A novel folate-decorated and graphene mediated drug delivery system was prepared that involves uniquely combining graphene oxide (GO) with anticancer drug for controlled drug release. The nanocarrier system was synthesized by attaching doxorubicin (DOX) to graphene oxide via strong pi-pi stacking interaction, followed by encapsulation of graphene oxide with folic acid conjugated chitosan. The pi-pi stacking interaction, simplified as a non-covalent type of functionalization, enables high drug loading and subsequent controlled release of the drug. The encapsulated graphene oxide enhanced the stability of the nanocarrier system in aqueous medium because of the hydrophilicity and cationic nature of chitosan. The loading and release of DOX indicated strong pH dependence and imply hydrogen-bonding interaction between graphene oxide and DOX. The proposed strategy is advantageous in terms of targeted drug delivery and has high potential to address the current challenges in drug delivery. Thus, the prepared nanohybrid system offers a novel formulation that combines the unique properties of a biodegradable material, chitosan, and graphene oxide for biomedical applications. (C) 2011 Elsevier B.V. All rights reserved.