An update on pancreatic pathophysiology (Do we have to rewrite pancreatic pathophysiology?)
An update on pancreatic pathophysiology (Do we have to rewrite pancreatic pathophysiology?)
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DOI：
10.1007/s10354-013-0260-y
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发表时间：
2014-02-01
影响因子：
0.9
通讯作者：
Hammer, Heinz F.
中科院分区：
文献类型：
--
作者：
Hammer, Heinz F.
This review focuses on seven aspects of physiology and pathophysiology of the exocrine pancreas that have been intensively discussed and studied within the past few years: (1) the role of neurohormonal mechanisms like melatonin, leptin, or ghrelin in the stimulation of pancreatic enzyme secretion; (2) the initiation processes of acute pancreatitis, like fusion of zymogen granules with lysosomes leading to intracellular activation of trypsinogen by the lysosomal enzyme cathepsin B, or autoactivation of trypsinogen; (3) the role of genes in the pathogenesis of acute pancreatitis; (4) the role of alcohol and constituents of alcoholic beverages in the pathogenesis of acute pancreatitis; (5) the role of pancreatic hypertension, neuropathy, and central mechanisms for the pathogenesis of pain in chronic pancreatitis; (6) the relation between exocrine pancreatic function and diabetes mellitus; and (7) pathophysiology, diagnosis and treatment of pancreatic steatorrhea.
