The Mediator captures CDK7, an attractive transcriptional target in cancer.
The Mediator captures CDK7, an attractive transcriptional target in cancer.
复制标题
Mediator 捕获 CDK7，这是癌症中一个有吸引力的转录靶标。
DOI：
10.1016/j.ccell.2021.07.021
复制
发表时间：
2021
期刊：
影响因子：
50.3
通讯作者：
Roberts,ThomasM
中科院分区：
文献类型：
--
作者：
Wang,Yubao;Manokaran,Cherubin;Wu,Su;Roberts,ThomasM
细胞周期蛋白依赖性激酶7（CDK7）参与调节癌症依赖性基因的表达，目前正在临床研究多种CDK7靶向治疗。最近的三项研究阐明了人类转录机制的结构，为CDK7功能和肿瘤中CDK7活性的潜在药效学标志物提供了重要的机制见解。
Cyclin-dependent kinase 7 (CDK7) is implicated in regulating the expression of cancer-dependent genes, and multiple CDK7-targeted therapies are currently under clinical investigation. Three recent studies elucidate the structure of human transcription machinery, offering vital mechanistic insights into CDK7 function and a potential pharmacodynamic marker of CDK7 activity in tumors.