Prenatal exposure to organophosphate pesticides, maternal paraoxonase 1 genotype, and childhood neurodevelopment at 24 months of age in Shandong, China.
Prenatal exposure to organophosphate pesticides, maternal paraoxonase 1 genotype, and childhood neurodevelopment at 24 months of age in Shandong, China.
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中国山东省产前有机磷农药暴露、母体对氧磷酶 1 基因型和 24 月龄儿童神经发育
DOI：
10.1007/s11356-019-06740-4
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发表时间：
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影响因子：
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通讯作者：
Tian Ying
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作者：
Wang Yiwen;Zhang Yan;Ji Lin;Zhou Yijun;Shi Rong;Kamijima Michihiro;Ueyama Jun;Gao Yu;Tian Ying
据报道，产前有机磷农药（OP）暴露对儿童神经发育产生负面影响。对氧磷酶1（PON 1）是OP代谢的关键酶，可能影响个体对OP暴露的易感性。然而，关于其在产前OP暴露和儿童神经发育的关联中的作用知之甚少。我们测量了母亲尿液中磷酸二甲酯（DM）、磷酸二乙酯（DE）和总二烷基磷酸盐（DAP）代谢产物（n= 436）以及母亲血液中PON 1 - 108 C/T和PON 1192 Q/R基因型（n= 244）。我们评估了母亲PON 1 - 108 C/T和PON 1192 Q/R基因型对中国山东24个月大儿童（n= 172）产前OP暴露和发育不良（DQ）之间关系的修饰作用。在携带PON 1 - 108 CC的母亲的孩子中，产前DM增加10倍与社交领域DQ评分下降5.72分相关。在携带PON 1192 QQ的母亲的孩子中，产前DM和DAP增加10倍分别与粗大运动域DQ评分下降7.68和7.67分相关。在携带PON 1192 QQ的母亲的孩子中，产前DM、DE和DAP增加10倍分别与社交领域DQ评分下降7.52、9.07和9.60分相关。母亲PON 1基因型可能会改变产前OP暴露与儿童24月龄神经发育之间的关联。
Prenatal organophosphate pesticide (OP) exposure was reported to negatively affect childhood neurodevelopment. Paraoxonase 1 (PON1) is a key enzyme in the metabolism of OPs and may affect an individual’s susceptibility to OP exposure. However, little is known about its role in the associations of prenatal OP exposure and childhood neurodevelopment. We measured dimethylphosphate (DM), diethylphosphate (DE), and total dialkylphosphate (DAP) metabolites in maternal urine (n= 436) as well as PON1–108C/T and PON1192Q/R genotypes in maternal blood (n= 244). We assessed the modifying effects of maternal PON1–108C/T and PON1192Q/R genotypes on relationships between prenatal OP exposure and developmental quotients (DQs) in 24-month-old children in Shandong, China (n= 172). Among children of mothers carrying PON1–108CC, a tenfold increase in prenatal DMs was associated with a 5.72-point decrease in social domain DQ scores. Among children of mothers carrying PON1192QQ, a tenfold increase in prenatal DMs and DAPs were associated with a 7.68- and 7.67-point decrease in gross motor domain DQ scores, respectively. Among children of mothers carrying PON1192QQ, a tenfold increase in prenatal DMs, DEs, and DAPs were associated with a 7.52-, 9.07-, and 9.60-point decrease in social domain DQ scores, respectively. Maternal PON1 genotype might modify the associations between prenatal OP exposure and children’s neurodevelopment at 24 months of age.