Use of a microbubble agent to increase the effects of high intensity focused ultrasound on liver tissue
Use of a microbubble agent to increase the effects of high intensity focused ultrasound on liver tissue
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DOI：
10.1007/s00330-005-2663-7
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发表时间：
2005-07-01
影响因子：
5.9
通讯作者：
Matsumoto, Y
中科院分区：
文献类型：
--
作者：
Kaneko, Y;Maruyama, T;Matsumoto, Y
为了探讨高强度聚焦超声(HIFU)对肝癌的治疗效果，我们分析了微气泡剂Levovist对HIFU引起的温度升高和组织坏死的影响。兔静脉注射左旋氧胆碱7ml(300 mg/ml)或生理盐水。用S(2.18 MHz，I-SPTA=400W/cm(2))对兔肝脏进行高强度聚焦超声(HIFU)，照射剂量为2.18 MHz。在HIFU开始后10min测量HIFU凝固组织的体积。服用Levovist的动物HIFU诱导的损伤更大：(mm(3)，Levovist vs生理盐水)371+/-104比166+/-71(P
In order to find out whether high intensity focused ultrasound (HIFU) might be useful against hepatocellular carcinoma, we analyzed the effect of a microbubble agent (Levovist) on the temperature rise and tissue necrosis induced by HIFU. Rabbits were given 7 ml Levovist (300 mg/ml) or saline intravenously. Up to six areas per rabbit liver were exposed to HIFU for 60 s (2.18 MHz, I-SPTA=400 W/cm(2)). The volume of the tissue coagulated by HIFU was measured 10 min after the start of HIFU. HIFU-induced lesions were larger in the animals given Levovist: (mm(3), Levovist versus saline) 371 +/- 104 versus 166 +/- 71 (P