Influence of early life stress on later hypothalamic-pituitary-adrenal axis functioning and its covariation with mental health symptoms: a study of the allostatic process from childhood into adolescence.
Influence of early life stress on later hypothalamic-pituitary-adrenal axis functioning and its covariation with mental health symptoms: a study of the allostatic process from childhood into adolescence.
复制标题
早期生活压力对后期下丘脑 - 垂体 - 肾上腺轴功能的影响及其与心理健康症状的协方差：从童年到青春期的同性恋过程的研究。
DOI：
10.1017/s0954579411000484
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发表时间：
2011-11
影响因子：
3.3
通讯作者：
Armstrong JM
中科院分区：
文献类型：
--
作者：
Essex MJ;Shirtcliff EA;Burk LR;Ruttle PL;Klein MH;Slattery MJ;Kalin NH;Armstrong JM
下丘脑-垂体-肾上腺 (HPA) 轴是变稳态过程中的主要机制，早期生活压力 (ELS) 通过该机制导致疾病。关于 ELS 对儿童 HPA 轴功能影响的研究得出了不一致的结果。为了解决这个问题，本研究在一项针对 357 名儿童的长期前瞻性社区研究中考虑了多种类型的 ELS（母亲抑郁、父亲抑郁和家庭表达愤怒）、心理健康症状和 HPA 功能的两个组成部分（特质样活动和时代特异性活动）。 ELS 在婴儿期和学龄前阶段进行评估；对 9、11、13 和 15 岁儿童的心理健康症状和皮质醇进行了评估。 3 级分层线性模型解决了有关 ELS 对 HPA 功能的影响及其与心理健康症状的共同变化的问题。 ELS 影响性状皮质醇水平和斜率，根据 ELS 的类型，过度唤醒和低唤醒都很明显。此外，ELS 的类型影响特定时期 HPA 功能和心理健康症状的共同变化，在之前接触过 ELS 的儿童中，HPA 改变与症状严重程度之间的耦合更紧密。结果强调了检查多种类型的 ELS 和动态 HPA 功能的重要性，以便捕捉青春期过渡期间展开的变稳态过程。
The hypothalamic-pituitary-adrenal (HPA) axis is a primary mechanism in the allostatic process through which early life stress (ELS) contributes to disease. Studies of the influence of ELS on children’s HPA axis functioning have yielded inconsistent findings. To address this issue, the present study considers multiple types of ELS (maternal depression, paternal depression, and family expressed anger), mental health symptoms, and two components of HPA functioning (trait-like and epoch-specific activity) in a long-term prospective community study of 357 children. ELS was assessed during the infancy and preschool periods; mental health symptoms and cortisol were assessed at child ages 9, 11, 13, and 15 years. A 3-level hierarchical linear model addressed questions regarding the influences of ELS on HPA functioning and its co-variation with mental health symptoms. ELS influenced trait-like cortisol level and slope, with both hyper- and hypo-arousal evident depending on type of ELS. Further, type(s) of ELS influenced co-variation of epoch-specific HPA functioning and mental health symptoms, with a tighter coupling of HPA alterations with symptom severity among children exposed previously to ELS. Results highlight the importance of examining multiple types of ELS and dynamic HPA functioning in order to capture the allostatic process unfolding across the transition into adolescence.