Gait variability in people with multiple sclerosis
Gait variability in people with multiple sclerosis
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DOI：
10.1177/1352458505070609
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发表时间：
2006-10-01
影响因子：
5.8
通讯作者：
Hudson, D. J.
中科院分区：
文献类型：
--
作者：
Crenshaw, S. J.;Royer, T. D.;Hudson, D. J.
多发性硬化症（MS）患者表现出不同的症状，这些症状在个体之间和个体内部可能不同。随着新的干预措施和药物治疗可用于MS患者，必须了解疲劳和功能活动性指标的变异性之间的关系，以确定MS人群中治疗引起的有意义的变化。本研究的目的是检查MS受试者在新鲜和疲劳条件下步态变异性的日内和日间变化。测量了20名诊断为MS的受试者和8名健康对照受试者的步行步态参数。髋关节、膝关节和踝关节运动学和动力学变量的标准差被量化为变异性的量度，并采用双向（按条件分组）ANOVA进行分析。结果表明，MS患者的髋关节（P < 0.020）、膝关节（P < 0.011）和踝关节（P < 0.034）关节角度变异性显著高于对照组，但不同条件之间的变异性无差异。动力学变异性在组间或条件下无差异。这项研究中的MS受试者比健康对照组走得更慢，他们也报告了更多的疲劳。检查MS人群中治疗效果的研究应考虑运动步态变异性水平的增加。
Patients with multiple sclerosis (MS) present with varying symptoms that can differ between and within individuals. As new interventions and drug treatments become available to MS patients, it is essential to understand the relationship between fatigue and the variability of functional mobility measures in order to define a meaningful change due to treatment within the MS population. The purpose of this study was to examine the within-day and between-day changes in gait variability for subjects with MS in fresh and fatigued conditions. Walking gait parameters were measured from 20 subjects diagnosed with MS and eight healthy control subjects. Standard deviations of hip, knee and ankle kinematic and kinetic variables were quantified as the measure of variability and analysed with a two-way (group by condition) ANOVA. Results indicated MS subjects had significantly greater hip (P < 0.020), knee (P < 0.011) and ankle (P < 0.034) joint angle variability than control subjects, but variability was not different between conditions. Kinetic variability was not different between groups or conditions. MS subjects in this study walked more slowly than the healthy controls and they also reported more fatigue. Research examining treatment effects within the MS population should account for increased levels of kinematic gait variability.