Shear stress, vascular remodeling and neointimal formation
Shear stress, vascular remodeling and neointimal formation
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DOI：
10.1016/s0021-9290(02)00446-3
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发表时间：
2003-05-01
影响因子：
2.4
通讯作者：
Krams, R
中科院分区：
文献类型：
--
作者：
Wentzel, JJ;Gijsen, FJH;Krams, R
剪切应力在动脉粥样硬化中的作用已被充分证明。然而，其在再狭窄中的作用暴露不足。本文将介绍一种新的体内测量技术及其在再狭窄研究中的应用。该技术由血管的3D重建和计算流体动力学（CFD）的组合组成。3D成像技术使用3D血管内超声（IVUS）作为独立技术或融合双平面血管造影和IVUS（安格斯）。应用计算流体动力学，以便将局部剪切应力分布与血管壁的形态相关联。在这些技术的应用中，将证明切应力在预测支架内再狭窄和球囊血管成形术后血管重塑中的新生内膜形成中起作用。通过新开发的分流器局部增加剪切应力的尝试表明，剪切应力可使支架内新生内膜形成减少50%。(C)2003爱思唯尔科技有限公司版权所有。
The role of shear stress in atherosclerosis has been well documented. However, its role in restenosis was underexposed. In this paper a novel in vivo measuring technique and several of its applications related to restenosis will be described. The technique consists of a combination of 3D reconstruction of blood vessels and computational fluid dynamics (CFD). The 3D imaging techniques use either of 3D intravascular ultrasound (IVUS) as a stand-alone technique or a fusion of biplane angiography and IVUS (ANGUS). CFD is applied in order to relate local shear stress distribution to the morphology of the vessel wall. In the applications of these techniques it will be demonstrated that shear stress plays a role in the prediction of neointimal formation in instent restenosis and in vascular remodeling after balloon angioplasty. Attempts to locally increase shear stress by a newly developed flow divider indicate that shear stress reduce in-stent neointimal formation by 50%. (C) 2003 Elsevier Science Ltd. All rights reserved.