Clinical Next Generation Sequencing for Precision Medicine in Cancer.
Clinical Next Generation Sequencing for Precision Medicine in Cancer.
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DOI：
10.2174/1389202915666150511205313
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发表时间：
2015-08
期刊：
影响因子：
2.6
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Dong L;Wang W;Li A;Kansal R;Chen Y;Chen H;Li X
低成本、高通量测序以及我们对人类疾病遗传基础理解的快速进步推动了下一代测序 (NGS) 在基因组医学中的快速采用。如今，NGS 方法已经在基因组研究的测序领域占据主导地位，并迅速进入临床实践。由于NGS的独特功能完美地满足了临床现实（需要事半功倍），NGS技术正在成为实现精准医疗梦想的驱动力。本文介绍了 NGS 的优势、精准医学中使用的 NGS 组合、NGS 在细胞学中的当前应用及其在常规临床应用中面临的挑战和未来方向。
Rapid adoption of next generation sequencing (NGS) in genomic medicine has been driven by low cost, high throughput sequencing and rapid advances in our understanding of the genetic bases of human diseases. Today, the NGS method has dominated sequencing space in genomic research, and quickly entered clinical practice. Because unique features of NGS perfectly meet the clinical reality (need to do more with less), the NGS technology is becoming a driving force to realize the dream of precision medicine. This article describes the strengths of NGS, NGS panels used in precision medicine, current applications of NGS in cytology, and its challenges and future directions for routine clinical use.