Fusiform gyrus volume reduction and facial recognition in chronic schizophrenia
Fusiform gyrus volume reduction and facial recognition in chronic schizophrenia
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DOI：
10.1001/archpsyc.60.4.349
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发表时间：
2003-04-01
影响因子：
--
通讯作者：
McCarley, RW
中科院分区：
文献类型：
--
作者：
Onitsuka, T;Shenton, ME;McCarley, RW
背景：梭状回（FG），又称枕颞回，被认为是负责面孔的加工和编码。值得注意的是，一些研究报告说，精神分裂症患者在面部处理方面表现出缺陷。因此，我们推测FG可能是精神分裂症患者面部识别异常的一个脑区。本研究的目的是确定是否有异常的前部和后部FG在慢性精神分裂症患者的灰质体积和FG亚区和即时和延迟记忆faces.Methods：患者被招募从波士顿VA医疗保健系统，布罗克顿司，并通过报纸广告招募对照组之间的关系。研究参与者包括21名被诊断为慢性精神分裂症的男性患者和28名男性对照组。参与者接受了高空间分辨率的磁共振成像，并评估了面部识别记忆。主要结果指标包括基于高空间分辨率磁共振成像的前部和后部FG灰质体积，使用三维信息进行详细可靠的手动描绘，以及FG子区域与来自Wechsler记忆量表III的即时和延迟面部记忆原始评分之间的相关系数。慢性精神分裂症患者的FG灰质体积（10%）总体上小于正常对照组。此外，精神分裂症患者在即时和延迟面部记忆测试中的表现比正常对照组更差。此外，延迟记忆的面孔表现不佳的程度显着相关的程度，双边前FG减少精神分裂症patients.Conclusion：这些结果表明，神经解剖FG异常的基础至少有一些赤字与面部识别精神分裂症。
Background: The fusiform gyrus (FG), or occipitotemporal gyrus, is thought to subserve the processing and encoding of faces. Of note, several studies have reported that patients with schizophrenia show deficits in facial processing. It is thus hypothesized that the FG might be one brain region underlying abnormal facial recognition in schizophrenia. The objectives of this study were to determine whether there are abnormalities in gray matter volumes for the anterior and the posterior FG in patients with chronic schizophrenia and to investigate relationships between FG subregions and immediate and delayed memory for faces.Methods: Patients were recruited from the Boston VA Healthcare System, Brockton Division, and control subjects were recruited through newspaper advertisement. Study participants included 21 male patients diagnosed as having chronic schizophrenia and 28 male controls. Participants underwent high-spatial-resolution magnetic resonance imaging, and facial recognition memory was evaluated. Main outcome measures included anterior and posterior FG gray matter volumes based on high-spatial-resolution magnetic resonance imaging, a detailed and reliable manual delineation using 3-dimensional information, and correlation coefficients between FG subregions and raw scores on immediate and delayed facial memory derived from the Wechsler Memory Scale III.Results: Patients with chronic schizophrenia had overall smaller FG gray matter volumes (10%) than normal controls. Additionally, patients with schizophrenia performed more poorly than normal controls in both immediate and delayed facial memory tests. Moreover, the degree of poor performance on delayed memory for faces was significantly correlated with the degree of bilateral anterior FG reduction in patients with schizophrenia.Conclusion: These results suggest that neuroanatomic FG abnormalities underlie at least some of the deficits associated I with facial recognition in schizophrenia.