Full genome sequences of two virulent strains of peste-des-petits ruminants virus, the Cote d'Ivoire 1989 and Nigeria 1976 strains
Full genome sequences of two virulent strains of peste-des-petits ruminants virus, the Cote d'Ivoire 1989 and Nigeria 1976 strains
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DOI：
10.1016/j.virusres.2008.04.018
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发表时间：
2008-09-01
期刊：
影响因子：
5
通讯作者：
Barrett, Thomas
中科院分区：
文献类型：
--
作者：
Chard, Louisa S.;Bailey, Dalan S.;Barrett, Thomas
小反刍动物害虫病毒（PPRV）在养殖和野生小反刍动物中引起急性发热性疾病，相关死亡率为50-80%。PPRV是副粘病毒家族中麻疹病毒属的一员，尽管有许多该家族成员的全长基因组序列，但它们对PPRV的可用性尤其有限。我们已经确定了科特迪瓦1989 （CI/89）和尼日利亚1976 （Ng76/1）两种PPRV毒株的全长序列。我们提出了这些病毒的启动子区域与其他可用的PPRV启动子序列的对齐，并确定了PPRV蛋白中被认为对副粘病毒启动子衰减至关重要的结构域。我们还分析了这些病毒的蛋白质，将它们与其他可用的PPRV蛋白质序列进行比较，并确定了以前被认为是其他副粘病毒蛋白质功能所必需的基序。(c) 2008 Elsevier B.V.版权所有
Peste-des-petits ruminants virus (PPRV) causes acute febrile illness in both farmed and wild small ruminants, with associated mortality rates of 50-80%. PPRV is a member of the Morbillivirus genus within the Paramyxovirus family and although there are many full length genome sequences available for members of this family, their availability for PPRV in particular is limited. We have determined the full length sequences representing two virulent strains of PPRV, the Cote d'Ivoire 1989 (CI/89) and Nigeria 1976 (Ng76/1) strains. We present an alignment of the promoter regions of these viruses with other available PPRV promoter sequences and have identified domains in PPRV proteins believed to be critical for paramyxovirus promoter attenuation. We have also analysed the proteins of these viruses, comparing them to other available PPRV protein sequences and identified motifs that were previously recognised as being required for the function of other paramyxovirus proteins. (c) 2008 Elsevier B.V. All rights reserved.