Optimal cutoff point of waist circumference and use of home blood pressure as a definition of metabolic syndrome: The Ohasama study
Optimal cutoff point of waist circumference and use of home blood pressure as a definition of metabolic syndrome: The Ohasama study
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DOI：
10.1038/ajh.2007.88
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发表时间：
2008-05-01
影响因子：
3.2
通讯作者：
Imai, Yutaka
中科院分区：
文献类型：
--
作者：
Sato, Atsushi;Asayama, Kei;Imai, Yutaka
背景：在家自测血压（HBP）比医院筛查血压（CBP）对心血管疾病的死亡率和发病率有更强的预测能力。没有研究评估自我测量的HBP诊断代谢综合征（MS）的临床意义。八个科学协会最近为日本人口定义了MS。然而，这一定义仍然存在争议，特别是关于腰围（WC）的截止值高于女性比男性。METHODS本人群为基础的调查的参与者是395名居民（>= 35岁）的Ohasama，日本农村社区。他们在2000年至2006年期间测量了HBP并进行了口服葡萄糖耐量试验。我们计算了诊断MS所需的WC的最佳截止值，并使用多变量分析研究了HBP与代谢危险因素聚类的相关性。ROC-TSACR操作特征分析表明，识别代谢危险因素聚类的最佳WC截止值在男性和女性分别为87和80 cm。升高的HBP显着相关的代谢危险因素的聚类，但CBP是不是。CONCLUSIONThe适当的WC截止值在目前的MS标准为日本妇女将是80厘米。我们认为，HBP将是有用的，当考虑MS的诊断。MS之间的关联确定使用HBP和心血管疾病（CVD）的预后需要进一步调查。
BACKGROUNDSelf-measured blood pressure (BP) at home (HBP) has a stronger predictive power for cardiovascular mortality and morbidity than casual-screening BP (CBP). No studies have evaluated the clinical significance of self-measured HBP for diagnosing metabolic syndrome (MS). Eight scientific associations recently defined MS for the Japanese population. However, this definition remains controversial, especially with respect to the cutoff value of waist circumference (WC) being higher in women than in men.METHODSThe participants of this population-based survey were the 395 residents (>= 35 years of age) of Ohasama, a rural Japanese community. They measured HBP and underwent the oral glucose tolerance test between the years 2000 and 2006. We calculated the optimal cutoff values of WC required to diagnose MS, and examined the association of HBP with metabolic risk-factor clustering using multivariate analyses.RESULTSReceiver operation characteristic analysis indicated that the optimal WC cutoff values for identifying clusters of metabolic risk factors were 87 and 80 cm in men and women, respectively. Elevated HBP was significantly associated with the clustering of metabolic risk factors but CBP was not.CONCLUSIONThe appropriate WC cutoff value in the current MS criteria for Japanese women would be 80 cm. We suggest that HBP would be useful when considering a diagnosis of MS. The association between MS determined using HBP and the prognosis of cardiovascular diseases (CVDs) requires further investigation.