Dietary cis and trans monounsaturated and saturated FA and plasma lipids and lipoproteins in men
Dietary cis and trans monounsaturated and saturated FA and plasma lipids and lipoproteins in men
复制标题
DOI：
10.1007/s11745-002-0871-9
复制
发表时间：
2002-02-01
期刊：
影响因子：
1.9
通讯作者：
Iwane, M
中科院分区：
文献类型：
--
作者：
Judd, JT;Baer, DJ;Iwane, M
与油酸相比，反式单不饱和脂肪酸 (TFA) 的胆固醇升高程度接近或相当于饱和 FA。然而，尚不清楚这些作用在多大程度上可能是由于油酸降低胆固醇而不是饱和 FA 和 TFA 升高胆固醇所致。为了更好地了解替代食品中 TFA 的影响，首先有必要了解随着 TFA 降低或去除而发生变化的主要 FA 的相对调脂作用。在随机 6 x 6 交叉设计中，5 名胆固醇正常的男性连续 5 周接受控制饮食，其中约 15% 的能量来自蛋白质，39% 来自脂肪，46% 来自碳水化合物。饮食中 8% 的能量被以下物质替代：碳水化合物 (CHO)（简单到复杂 1:1）；油酸（OL）；三氟乙酸；硬脂酸（STE）； TFA\STE（各占 4% 的能量）；碳12:0-16:0饱和FA（LMP）。 LDL胆固醇浓度(mmol/L)如下(不同上标表示P≤0.01时显着)：OL 2.95(a)； CHO 3.05(a，b)； STE 3.10(b,c)； LMP 3.21(c,d)； TFA + STE 3.32(d,e)；和 TFA 3.36(e)。 HDL 胆固醇浓度 (mmol/L) 允许：STE 1.16(a)； TFA 1.16(a,b)； TFA\STE 1.17(a,b)； CHO 1.19(b)； OL 1.24(c)；和 LMP 1.30(d)。三酰基甘油酯在 STE 后最高 (1.13)，在 OIL 后最低 (0.88) P
Trans monounsaturated fatty acids (TFA) are hypercholesterolemic compared to oleic acid to a degree approaching or equivalent to saturated FA, However, it is unknown to what extent these effects may be due to cholesterol lowering by oleic acid rather than elevation by saturated FA and TFA. In order to better understand the impact of replacing TFA in foods, it is first necessary to know the relative lipid-modifying effects of the major FA that change as TFA are lowered or removed. For 5 wk, 50 normocholesterolemic men were fed controlled diets providing approximately 15% of energy from protein, 39% from fat, and 46% from carbohydrate in a randomized, 6 x 6, crossover design. Eight percent or energy was replaced across diets with the following: carbohydrate (CHO) (1:1 simple to complex); oleic acid (OL); TFA; stearic acid (STE); TFA\STE (4% of energy from each); carbon 12:0-16:0 saturated FA (LMP). LDL cholesterol concentrations (mmol/L) were as follows (different superscripts indicate significance at P less than or equal to 0.01): OL 2.95(a); CHO 3.05(a,b); STE 3.10(b,c); LMP 3.21(c,d); TFA + STE 3.32(d,e); and TFA 3.36(e). HDL cholesterol concentrations (mmol/L) were as allows: STE 1.16(a); TFA 1.16(a,b); TFA\STE 1.17(a,b); CHO 1.19(b); OL 1.24(c); and LMP 1.30(d). Triacyl glycerides were highest after STE (1.13) and lowest after OIL (0.88) P