Bioengineering organs using small intestinal submucosa scaffolds:: In vivo tissue-engineering technology
Bioengineering organs using small intestinal submucosa scaffolds:: In vivo tissue-engineering technology
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DOI：
10.1089/end.2000.14.59
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发表时间：
2000-02-01
影响因子：
2.7
通讯作者：
Cheng, EY
中科院分区：
文献类型：
--
作者：
Kropp, BP;Cheng, EY
组织工程学是一个很有前途的研究领域，有可能带来膀胱重建的革命性变化。目前，两种诱导膀胱再生的技术正在研究中，第一种是体内技术，涉及使用可生物降解的支架，宿主膀胱可以用来重塑和再生。这项技术利用了细胞的自然修复或再生能力，使其恢复到正常状态。第二项技术，体外技术，涉及从宿主的天然膀胱建立原代细胞培养。这些细胞种植在可生物降解的支架上，形成复合移植物，然后移植回宿主体内，继续再生过程。显然，这两种技术各有优缺点，都将在未来的尿路重建中发挥一些作用。到目前为止，利用体内技术取得的最成功的结果是小肠粘膜下层(SIS)，在本文中，我们讨论了体内组织工程技术以及利用SIS进行的尿路再生的临床前研究。
Tissue engineering is a promising field of research that has the potential to revolutionize urinary bladder reconstruction. Currently, two techniques for the induction of bladder regeneration are being researched, The first, the in vivo technique, involves the use of a biodegradable scaffold that the host bladder can use to remodel and regenerate. This technique takes advantage of the cell's natural ability to heal or regenerate itself back to a normal state. The second technology, the in vitro technique, involves establishment of primary cell cultures from the host's native bladder. These cells are seeded on a biodegradable scaffold to create a composite graft that is then transplanted back into the host for continuation of the regeneration process. Clearly, both techniques have advantages and disadvantages, and both will have some role in future urinary reconstruction. To date, the most successful results utilizing in vivo techniques have been with small intestinal submucosa (SIS), In this article, we discuss in vivo tissue engineering technology and the preclinical studies that have been performed utilizing SIS for urinary tract regeneration.