Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons
Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons
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DOI：
10.1038/nn1517
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发表时间：
2005-09-01
影响因子：
25
通讯作者：
Feldman, JL
中科院分区：
文献类型：
--
作者：
McKay, LC;Janczewski, WA;Feldman, JL
消融preBotzinger复合体（preBotC）神经元，呼吸节律的产生至关重要，导致在一个渐进的，越来越严重的呼吸模式中断，最初在睡眠期间，然后也在清醒的成年大鼠。睡眠呼吸障碍在老年人和一些神经退行性疾病患者中非常普遍。我们认为睡眠呼吸障碍是由preBotC神经元的丢失引起的，可能是这些人群睡眠期间死亡的原因。
Ablation of preBotzinger complex (preBotC) neurons, critical for respiratory rhythm generation, resulted in a progressive, increasingly severe disruption of respiratory pattern, initially during sleep and then also during wakefulness in adult rats. Sleep-disordered breathing is highly prevalent in elderly humans and in some patients with neurodegenerative disease. We propose that sleep-disordered breathing results from loss of preBotC neurons and could underlie death during sleep in these populations.