Manipulation of Rat Movement via Nigrostriatal Stimulation Controlled by Human Visually Evoked Potentials.
Manipulation of Rat Movement via Nigrostriatal Stimulation Controlled by Human Visually Evoked Potentials.
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DOI：
10.1038/s41598-017-02521-6
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发表时间：
2017-05-24
影响因子：
4.6
通讯作者：
Shin HC
中科院分区：
文献类型：
--
作者：
Koo B;Koh CS;Park HY;Lee HG;Chang JW;Choi S;Shin HC
在这里，我们报告了脑对脑接口（BBI）系统的开发，该系统使人类用户无需任何事先训练即可操纵老鼠的运动。在我们的模型中，远程引导的老鼠（称为大鼠机器人）通过基于人类控制器稳态视觉诱发电位（SSVEP）的脑机接口（BCI）对黑质纹状体（NS）通路的电刺激诱导的对侧转向行为，成功地在T型迷宫中导航。该系统允许人类参与者操纵老鼠的运动，平均成功率为 82.2%，老鼠的平均速度约为 1.9 米/分钟。老鼠机器人没有方向偏好，左转和右转任务的平均成功率分别为 81.1% 和 83.3%。这是第一项证明使用 NS 刺激来开发高度稳定的大鼠机器人的研究，该机器人不需要事先训练，并且是用于大鼠导航的免训练 BBI 的第一个实例。这项研究的结果将促进人类和未经训练的动物之间无国界交流的发展，这不仅可以提高人类对动物的理解，还可以让未经训练的动物更有效地向人类提供以其优越感知所获得的信息。
Here, we report that the development of a brain-to-brain interface (BBI) system that enables a human user to manipulate rat movement without any previous training. In our model, the remotely-guided rats (known as ratbots) successfully navigated a T-maze via contralateral turning behaviour induced by electrical stimulation of the nigrostriatal (NS) pathway by a brain- computer interface (BCI) based on the human controller’s steady-state visually evoked potentials (SSVEPs). The system allowed human participants to manipulate rat movement with an average success rate of 82.2% and at an average rat speed of approximately 1.9 m/min. The ratbots had no directional preference, showing average success rates of 81.1% and 83.3% for the left- and right-turning task, respectively. This is the first study to demonstrate the use of NS stimulation for developing a highly stable ratbot that does not require previous training, and is the first instance of a training-free BBI for rat navigation. The results of this study will facilitate the development of borderless communication between human and untrained animals, which could not only improve the understanding of animals in humans, but also allow untrained animals to more effectively provide humans with information obtained with their superior perception.