An optimal combination of MCCB and CANTAB to assess functional capacity in older individuals with schizophrenia
An optimal combination of MCCB and CANTAB to assess functional capacity in older individuals with schizophrenia
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DOI：
10.1002/gps.4547
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发表时间：
2016-10-01
影响因子：
4
通讯作者：
Rajji, Tarek K.
中科院分区：
文献类型：
--
作者：
Kumar, Sanjeev;Mulsant, Benoit H.;Rajji, Tarek K.
简介：认知缺陷预测精神分裂症患者包括晚年的功能能力。矩阵共识认知电池（MCCB）和剑桥神经心理测试自动化电池（CANTAB）被广泛用于评估这一人群的认知。本研究的目的是确定与老年精神分裂症患者的功能能力密切相关的两个电池的最小亚测试集。方法：60名年龄在50岁或以上，诊断为精神分裂症或分裂情感性障碍的参与者和30名对照组参与者被纳入研究。认知采用MCCB和CANTAB进行评估，功能能力采用USCD绩效技能评估（UPSA）进行评估。采用逐步线性回归来确定与功能能力相关的最佳认知测试集。结果：UPSA总分与年龄呈负相关，与学历、MCCB总分呈正相关。大多数MCCB域和子测试，以及几个CANTAB子测试与UPSA总分相关。在回归模型中，MCCB总体得分占UPSA方差的42.5%。相比之下，只有四个子测试（MCCB的加工速度和言语学习，CANTAB的情感信息加工和工作记忆）的组合占UPSA方差的60%。结论：MCCB和CANTAB的表现与老年精神分裂症患者的功能能力密切相关。MCCB和CANTAB亚测试的选择性组合可能同样有效地评估晚期精神分裂症的功能能力。版权所有：John Wiley & Sons， Ltd。
Introduction: Cognitive deficits predict functional capacity in patients with schizophrenia including in late life. The MATRICS Consensus Cognitive Battery (MCCB) and the Cambridge Neuropsychological Test Automated Battery (CANTAB) are widely used to assess cognition in this population. The aim of this study was to determine a minimal set of subtests across the two batteries that would be strongly associated with functional capacity in older patients with schizophrenia.Methods: Sixty participants age 50 years or older with a diagnosis of schizophrenia or schizoaffective disorder and 30 control participants were enrolled. Cognition was assessed using the MCCB and the CANTAB. Functional capacity was assessed using the USCD Performance-based Skills Assessment (UPSA). Stepwise linear regressions were performed to determine the best set of cognitive tests associated with functional capacity.Results: UPSA total score was negatively correlated with age and positively correlated with education and the MCCB global score. Most of the MCCB domains and subtests, and several of the CANTAB subtests correlated with UPSA total score. In the regression model, MCCB global score accounted for 42.5% of UPSA variance. In contrast, a combination of only four subtests (processing speed and verbal learning from the MCCB, and affective information processing and working memory from the CANTAB) accounted for 60% of UPSA variance.Conclusions: Performance on MCCB and CANTAB is strongly associated with functional capacity in older patients with schizophrenia. A selective combination of MCCB and CANTAB subtests may be as effective in assessing functional capacity in late life schizophrenia. Copyright (C) 2016 John Wiley & Sons, Ltd.