Enantioselective Michael reaction of malonates and chalcones by phase-transfer catalysis using chiral quaternary ammonium salt
Enantioselective Michael reaction of malonates and chalcones by phase-transfer catalysis using chiral quaternary ammonium salt
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DOI：
10.1016/s0040-4039(01)01237-0
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发表时间：
2001-09-03
影响因子：
1.8
通讯作者：
Kim, SM
中科院分区：
文献类型：
--
作者：
Kim, DY;Huh, SC;Kim, SM
报道了以季铵盐为相转移催化剂，以辛可尼定为原料，催化进行了对映选择性Michael反应。在温和的反应条件下，用查尔酮衍生物处理丙二酸酯，可得到相应的迈克尔加合物，产率高，对映体过量。2001爱思唯尔科学有限公司版权所有。
The catalytic enantioselective Michael reaction promoted by quaternary ammonium salt from cinchonidine as a phase-transfer catalyst is described. Treatment of malonate with chalcone derivatives under mild reaction conditions afforded the corresponding Michael adducts in good yields with good to moderate enantiomeric excesses. (C) 2001 Elsevier Science Ltd. All rights reserved.