Understanding conserved amino acids in proteins
Understanding conserved amino acids in proteins
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DOI：
10.1016/s0378-4371(02)01079-8
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发表时间：
2002-11-01
影响因子：
3.3
通讯作者：
Shakhnovich, EI
中科院分区：
文献类型：
--
作者：
Dokholyan, NV;Mirny, LA;Shakhnovich, EI
已经证实，进化施加压力以保存具有热力学、动力学和功能作用的氨基酸。在这封信中，我们表明，物理要求，以保持蛋白质的稳定性引起了序列保守性模式，这是在显着的协议，在天然蛋白质。基于氨基酸的物理性质，我们提出了一个进化模型，解释了跨蛋白质家族共享相同折叠的保守氨基酸。(C)2002 Elsevier Science B.V.保留所有权利。
It has been conjectured that evolution exerted pressure to preserve amino acids bearing thermodynamic, kinetic, and functional roles. In this letter we show that the physical requirement to maintain protein stability gives rise to a sequence conservatism pattern that is in remarkable agreement with that found in natural proteins. Based on the physical properties of amino acids, we propose a model of evolution that explains conserved amino acids across protein families sharing the same fold. (C) 2002 Elsevier Science B.V. All rights reserved.