Stress, social support, and delayed skin barrier recovery.
Stress, social support, and delayed skin barrier recovery.
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压力、社会支持和皮肤屏障恢复延迟。
DOI：
10.1097/psy.0b013e318157b12e
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发表时间：
2007
影响因子：
3.3
通讯作者：
Robles,TheodoreF
中科院分区：
文献类型：
--
作者：
Robles,TheodoreF
目的：研究短暂的实验室应激源和应激源前的社会支持对心血管和皮质醇反应以及皮肤破裂后皮肤屏障恢复的影响。方法：85名健康受试者(平均年龄22.9±4.4岁)接受了破坏正常皮肤屏障功能的“剥离”程序，并被随机分配到无应激组(阅读任务)、应激组(Trier社会压力测试)和压力+社会支持组(应激源前来自邦联的支持)。结果：与无应激状态相比，应激源使皮肤损伤后2小时皮肤屏障恢复延迟10%(效应大小，r=0.0 5)。29)，并增加焦虑(r=.24)、负性情感(r=.22)、心血管活动(r值来自。4-。6)，在男性参与者中，皮质醇水平(r=40)。社会支持不影响心理或生理反应或皮肤屏障恢复。对这些任务的较大生理反应并不预示皮肤屏障恢复较慢。相反，更大的收缩压反应预示着更快的皮肤屏障恢复(r=。结论：本研究复制了短期实验室应激源对皮肤屏障恢复的影响，进一步确立了皮肤屏障恢复与未来研究的相关性。支持操作没有影响生理反应或皮肤屏障恢复，这表明未来关于社会支持、生理学和客观健康结果的研究应该集中在自然社会互动、关系和压力源上。
Objective:To examine the effect of a brief laboratory stressor and social support before the stressor on cardiovascular and cortisol responses, and skin barrier recovery after skin disruption.Methods:Eighty-five healthy participants (mean age 22.9±4.4 years) underwent a “tape-stripping” procedure that disrupts normal skin barrier function, and were randomly assigned to a No Stress (reading task), Stress (Trier Social Stress Test), or Stress+ Social Support condition (support from a confederate before the stressor). Skin barrier recovery was assessed by measuring transepidermal water loss from up to 2 hours after skin disruption.Results:Compared with the No Stress condition, the stressor delayed skin barrier recovery by 10% at 2 hours after skin disruption (effect size, r=. 29), and increased anxiety (r=. 24), negative affect (r=. 22), cardiovascular activity (r values from. 4–. 6), and among male participants, cortisol levels (r=. 40). Social support did not influence psychological or physiological responses or skin barrier recovery. Larger physiological responses to the tasks did not predict slower skin barrier recovery. Instead, larger systolic blood pressure responses predicted faster skin barrier recovery (r=. 26).Conclusions:This study replicated the effects of short-term laboratory stressors on skin barrier recovery, further establishing the relevance of skin barrier recovery for future research. The support manipulation did not influence physiological responses or skin barrier recovery, suggesting that future research on social support, physiology, and objective health outcomes should focus on naturalistic social interactions, relationships, and stressors.